来曲唑联合促性腺素促排卵在IVF-ET中的临床应用  

Clinical application on controlled ovarian stimulation using the Letrozole combined with gonadotropins for in vitro fertilization and embryo transfer

作　　者：江成龙[1] 郑蓉[2] 王华[1] 彭海英[1] 罗清炳[1] 张昌军[1] 

机构地区：[1]郧阳医学院附属人民医院生殖医学中心,湖北十堰442000 [2]郧阳医学院附属太和医院妇产科

出　　处：《中国妇幼保健》2010年第2期219-221,共3页Maternal and Child Health Care of China

基　　金：湖北省教育厅科研项目(B20092411)

摘　　要：目的:研究来曲唑联合促性腺激素(Gn)促排卵在体外受精胚胎移植(IVF-ET)中的应用。方法:将237例不孕患者336个完整IVF-ET助孕周期随机分成GnRHa短方案组146周期和来曲唑促排卵组190周期,比较两组的促排卵参数和临床结局。结果:来曲唑促排组促排天数、Gn总量、诱导日E2、获卵数、MII卵的百分率显著低于短方案促排卵组(P<0.05),诱导日LH、P显著高于短方案组(P<0.05),而两组的受精率、卵裂率、优质胚胎率、移植胚胎数、种植率、临床妊娠率、流产率均无统计学差异(P>0.05)。结论:来曲唑联合Gn促排卵在不影响临床妊娠率的前提下能减少Gn使用剂量,降低治疗费用,是一种很有应用前景的IVF-ET促排卵方案。Objective： To study the efficacy of the Letrozole combined with gonadotropins on the controlled ovarian stimulation for in vitro fertilization and embryo transfer. Methods： 237 patients, 336 cycles were divided into short GnRHa protocol group （n = 145） and the Letrozole group （n = 190） . Parameter of controlled ovarian stimulation and clinical effect in the two groups were compared Results： Patient characteristics were similar between the two groups. There were no significant differences in mean age, the distribution of indications for IVF , fertilization rates, pregnancy rates , abort rate, implantation rate , number of embryos transferred, or embryo score. Peak E2 levels , duration or doses of gonadotropins required, number of oocytes, or percentage of mature oocytes obtained were significantly lower while the P and LH level on the induce day were significantly higher in the Letrozole group. Conclusion： The Letrozole combined with gonadotropins on controlled ovarian stimulation for IVF - ET will not harmful to the outcome of IVF but can reduce the duration or doses of gonadotropins required compared with the short GnRHa protocol.

关 键 词：来曲唑 促排卵 IVF—ET 

分 类 号：R714.13[医药卫生—妇产科学]