常规烧伤处理结合抗炎灵口服预防重度烧伤后SIRS和MODS的临床效果观察  

Clinical Observation of Integrated Traditional and Western Medicine for Preventing SIRS/ MODS after Severe Burns

作　　者：宋知仁[1] 郑建锋[1] 冷明芳[2] 成路[1] 刘奇[1] 罗友云[1] 

机构地区：[1]解放军169医院烧伤整形科,湖南衡阳421002 [2]解放军169医院消化中心,湖南衡阳421002

出　　处：《医学临床研究》2010年第1期94-96,共3页Journal of Clinical Research

摘　　要：【目的】探讨中药抗炎灵在预防重度烧伤后全身炎症反应综合征（SIRS）和多器官功能障碍综合征（MODS）中的作用。【方法】重度烧伤患者43例，随机分为中药组22例，对照组21例；对照组按常规烧伤处理，中药纽在对照纽的基础上加用中药抗炎灵煎剂。观察两纽治疗前后胃黏膜改变（胃镜下）及胃黏膜pH值（张力计法），中毒性肠麻痹、SIRS／MODS的发生率。【结果】治疗10d后，胃镜观察显示：中药组患者胃黏膜病变的发生率为31．82％，明显低于对照组61．90％（P〈0．05）；胃黏膜pH值：治疗72h后与治疗前比较，两纽均有提高，但中药组（7．335±0．063）比对照组（7．013±0．102）升高明显（P〈0．05）；中毒性肠麻痹、SIRS／MODS的发生率均明显低于对照组（P〈0．05）。【结论】中药抗炎灵能有效预防重度烧伤后SIRS／MODS的发生。[Objective]To study the effect of traditional Chinese medicine（TCM） on systemic inflammatory response syndrome（SIRS） and multiple organ dysfunction syndrome（MODS） after severe burns. [Methods] Forty three patients with severe burns were divided randomly into TCM group （n=22） and control group（n=21）. TCM group received routine burn remedy plus TCM apozem. Control group only received routine burn remedy. The changes of gastric mucosa under gastroscope and PH of gastric mucosa by tensiometer method, the incidence of toxic enteroparalysis and SIRS/MODS were observed. [Results]After treatment for 10 days, the incidence of gastric mucosa lesion was 31.28%, which was obviously lower than that of control group （61. 90%） （ P 〈20.05）. PH of gastric mucosa in two groups after treatment was higher than that at 72 hours before treatment, but PH of TCM group（7. 335±0. 063） was obviously higher than that of control group （7. 013 ±0. 102, P 〈20.05）. The incidence of toxic enteroparalysis and SIRS/MODS was much less than that of control group （ P 〈20.05）. [Conclusion]TCM can prevent the incidence of SIRS/MODS after severe burns.

关 键 词：烧伤/并发症 多器官功能衰竭/预防和控制 多器官功能衰竭/中西医结合疗法 

分 类 号：R644[医药卫生—外科学]