复脉Ⅰ号对大鼠心肌和主动脉^(45)Ca跨膜流动的影响  

Effect of FumaiⅠon ^(45)Ca Transmembrane Flow in Rats Cardiac Muscle and Aorta

作　　者：周青罡[1,2] 李卉芳[1] 莫尚武[3] 李文宏[1] 陈奇[1] 

机构地区：[1]江西中医学院药学系,南昌330006 [2]汇仁集团研发部,上海20120306 [3]四川大学原子核科学技术研究所,成都610064

出　　处：《中药新药与临床药理》2010年第1期26-28,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金(39860084);江西省教育厅课题(赣教批字2001年387号)

摘　　要：目的采用血清药理学方法,研究复脉汤有效部位(复脉Ⅰ号)对大鼠心肌和主动脉45Ca内流和外溢的影响规律,探讨复脉Ⅰ号抗心律失常的药理机制。方法应用45Ca跨膜测量技术研究复脉Ⅰ号含药血清对大鼠心肌和主动脉电压依赖钙通道(PDC)的影响。结果复脉Ⅰ号含药血清对大鼠心肌和主动脉45Ca跨膜流动的影响显著,既能阻滞45Ca大量内流,又能促进已流入细胞内的45Ca外溢。结论复脉Ⅰ号抗心律失常的机理可能与阻滞细胞膜外Ca2+内流,促进膜内Ca2+外溢,维持细胞内Ca2+浓度的稳定有关。Objective To study the antiarrhythmic mechanism of Fumai I （the effective part of Fumai Decoction ） about ^45Ca influx and efflux in rats cardiac muscle and aorta by serum pharmacological technique. Methods ^45Ca transmembrane influx technique was used to study the influence of serum containing Fumai I on potential -dependent calcium channel （PDC） in rats cardiac muscle and aortas. Results The serum of Fumai I had significant effect on ^45Ca channel of cardiac muscle and aorta in rats. It can not only block ^45Ca coming into ceils, but also can facilitate efflux of ^45Ca in the cell. Conclusion The antiarrhythmic mechanism of Fumai I may be related with blocking ^45Ca inflUX into the cells, facilitating ^45Ca efflux out and keeping Ca2^＋ balance in the cells.

关 键 词：复脉汤 有效部位 同位素45Ca 电压依赖钙通道(PDC) 血清药理学 

分 类 号：R285.5[医药卫生—中药学]