均匀设计湿法粉碎提取精制冠心方的工艺研究  

Optimization of Wet-shattering Extraction Process of Jingzhi Guanxin Recipe with Uniform Design Method

作　　者：李巧如[1] 宋文惠[1] 赵波[1] 

机构地区：[1]陕西省人民医院药剂科,西安市710068

出　　处：《中药新药与临床药理》2010年第1期73-75,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：陕西省社发攻关资助项目(2008K16-04)

摘　　要：目的优选精制冠心方的提取工艺。方法采用均匀设计法,以丹参酮ⅡA、丹酚酸B、芍药苷、阿魏酸、羟基红花黄色素A含量及出膏率为指标,优选湿法粉碎提取精制冠心方的最佳工艺。结果最优提取工艺为取精制冠心方药材粗粉,第一次加6倍量95%乙醇,粉碎提取10min,第二次加6倍量60%乙醇,粉碎提取10min,第三次加6倍量20%乙醇,粉碎提取10min。结论均匀设计法试验优选的精制冠心方湿法粉碎提取工艺,各成分提出量比原工艺明显提高,节约时间、操作简单。Objective To optimize the extraction process of Jingzhi Guanxin Recipe. Methods With the amounts of tanshinone ⅡA, salvianolic acid B, paeoniflorin, ferulic acid and hydroxysaffior yellow A as observation parameters, uniform design method was used for the optimization of wet - shattering extraction process of Jingzhi Guanxin Recipe. Results The optimum extraction process was as follows： adding 6 - fold 95 % alcohol for the first time of exaction, adding 6 - fold 60 % alcohol for the second time, adding 6 - fold 20 % alcohol for the third time, and shattering for 10 minutes every time. Conclusion This optimized process is efficient, economic and simple.

关 键 词：精制冠心方 均匀设计 湿法粉碎提取 工艺研究 

分 类 号：R284[医药卫生—中药学] TQ460.6[医药卫生—中医学]