IL-1β与人慢性胃炎的相关性研究  

Correlation between IL-1β and chronic gastritis

作　　者：乔文[1] 李娜 李长顺[1] 薛挥[1] 

机构地区：[1]西安交通大学医学院第一附属医院消化科,陕西西安710061 [2]兵器工业部521医院消化科

出　　处：《胃肠病学和肝病学杂志》2010年第1期47-48,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨IL-1β与人慢性胃炎之间的相关性。方法收集西安交通大学医学院第一附属医院胃镜检查的胃活检标本,福尔马林固定,制备石蜡切片,进行病理分型和IL-1βSABC免疫组化染色。结果慢性萎缩性胃炎组IL-1β表达的阳性率高于慢性浅表性胃炎组(P<0.05);慢性萎缩性胃炎组中,异型增生组IL-1β表达的阳性率高于肠腺化生组(P<0.05)。结论IL-1β在慢性胃炎的转归和发展中具有较高的预测价值。Objective To discuss the correlation between IL-1β and chronic gastritis.Methods The gastric biopsy specimens were collected by gastroscopy for pathologic examination.In the meantime,IL-1β was detected by SABC immunohistochemistry.Results The positive rate of IL-1β in chronic atrophic gastritis group was higher than that in chronic superficial gastritis group（P0.05）.In the chronic atrophic gastritis group,the positive rate of IL-1β in dysplasia group was higher than that in intestinal metaplasia group（P0.05）.Conclusion IL-1β has a higher predictive value in the prognosis of chronic gastritis.

关 键 词：IL-1Β 慢性胃炎 

分 类 号：R392.11[医药卫生—免疫学] R573.3[医药卫生—基础医学]