盐酸左氧氟沙星在健康人体内的药代动力学研究  

Pharmacokinetics of Levofloxacin Hydrochloride in Healthy Volunteers

作　　者：孙曼春[1] 方世平[1] 王智勇[1] 吴建元[1] 袁娴芬[1] 

机构地区：[1]武汉大学中南医院,湖北武汉430071

出　　处：《中国药业》2010年第3期5-6,共2页China Pharmaceuticals

摘　　要：目的研究盐酸左氧氟沙星在健康人体内的药代动力学。方法20例健康男性志愿者均单剂量口服盐酸左氧氟沙星片200mg,采用高效液相色谱法测定给药前及给药后24h内不同时点的血药浓度,采用DAS1.0程序计算药代动力学参数。结果盐酸左氧氟沙星在健康人体内的主要药代动力学参数吸收相半衰期t1/2ka为(0.233±0.060)h、消除相半衰期t1/2β为(9.628±5.213)h、表观分布容积Vd为(1.795±0.918)L、分布相半衰期t1/2α为(1.188±0.726)h、药时曲线下面积(AUC0→24)为(24.385±3.222)mg/(L·h)、药时曲线下总面积AUC0→∞(29.866±3.892)mg/(L·h)。结论盐酸左氧氟沙星的药代动力学过程符合一级吸收二室模型。Objective To study the pharmacokinetics of levofloxacin hydrochloride in healthy human. Methods 20 healthy male volunteers were given each a single oral dose of 200 mg of levofloxacin hydrochloride tablets. The concentrations of levofloxacin hydrochloride in the blood plasma before the administration and at different time points within 24 h after the medication were determined with HPLC. The stationary phase was Diamonsil C18 chromatographic column （250 mm ×4.6 mm, 5 μm）; the mobile phase was acetonitrile-0.04 mol/L phosphoric acid： triethylamine （2：8：0.02, V/V）; the flow rate was 1.0 mL/min; the column temperature was 30℃; the detect wavelength was 298 nm.The DAS 1.0 program was used to calculate the pharmacokinetics parameters. Results The management process of levofloxacin hydrochloride in the human body after the administration accorded with the two-compartment open model with a first order absorption. The main pharmacokinetics parameters of the drug were as follows： t1/2ks （0. 233±0. 060） h, t1/2β （9. 628±5. 213） h, Vd （1. 795±0. 918） L, t1/2α （1. 188±0. 726） h, AUC0→24 （24. 385±3. 222） mg/h·L, AUC0→∞（29. 866±3. 892） mg/h ~ L Conclusion The pharmacokinetics process of levofloxacin hydrochloride in the human body is shown to be in accordance with the two- compartment open model with a first order absorption.

关 键 词：盐酸左氧氟沙星 药代动力学 高效液相色谱法 

分 类 号：R969.1[医药卫生—药理学] R978.69[医药卫生—药学]