葛根素对糖尿病模型大鼠尿清蛋白排泄率的影响  

Effect of Puerarin on Urinary Albumin Excretion Rate of Diabetic Rats

作　　者：崔秀玲[1] 王远征[2] 刘晓健[3] 

机构地区：[1]辽宁医学院附属第三医院 [2]辽宁医学院附属第一医院高级医疗服务中心 [3]辽宁医学院药理教研室,锦州121001

出　　处：《医药导报》2010年第2期163-164,共2页Herald of Medicine

摘　　要：目的观察葛根素对糖尿病大鼠尿清蛋白排泄率的影响,考察该药对糖尿病肾损害的保护作用。方法将SD大鼠随机分为正常对照组(A组)、糖尿病组(B组)和葛根素低、中、高剂量组(C、D、E组)。B、C、D、E组制备糖尿病模型,C、D、E组分别腹腔注射葛根素注射液40,80,160mg.kg-1.d-1,A、B组腹腔注射等容量0.9%氯化钠溶液,均连续8周。分别于实验第2,4,8周测定大鼠尿清蛋白排泄率。结果各时间点葛根素治疗组尿清蛋白排泄率均高于A组,但明显低于B组(P<0.01或P<0.05)。结论葛根素可以减轻糖尿病模型大鼠肾小球损害,降低尿清蛋白排泄率,对糖尿病大鼠肾脏有一定保护作用。Objective To investigate effects of puerarin on urinary albumin excretion rate of diabetic rats, and explore the protection of which against renal damage. Methods SD rats were randomly assigned to normal control group （A） , diabetic group （B） ,puerarin at a low-dose （ C）, middle-dose （ D）, high-dose group （E）. Rats in group C, D, E were i. p. treated with puerarin 40,80,160 mg · kg^-1· d^-1, respectively; those in group A and B were treated with sodium chloride at the same volume. The urinary excretion rates of albumin were tested at the second, fourth and eighth week. Results The urinary protein excretion of albumin in group C, D, E at three time points were all higher than those in group A, but much lower than those in group B （P 〈 0.01 or P 〈 0.05 ）. Conclusion Puerarin could attenuate glomeruli injury, reduce urinary albumin excretion of diabetic rats and play a role in protecting kidneys of diabetic rats.

关 键 词：葛根素 糖尿病 糖尿病肾病 尿清蛋白 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]