严重抗结核药物过敏反应12例临床分析  

CLINICAL ANALYSIS ON 12 CASES OF SEVERE ALLERGIC REACTION OF ANTI-TB DRUGS

作　　者：谭毅刚[1] 李嫣红[1] 傅红梅[1] 钟洪兰[1] 周颖 

机构地区：[1]广州市胸科医院,广东广州510095 [2]广州市肝病医院,广东广州510000

出　　处：《现代医院》2010年第1期33-35,共3页Modern Hospitals

摘　　要：目的提高对服用抗结核药后所出现过敏反应症状的认识,减少延误诊治。方法回顾性分析2006年6月～2008年12月广州市胸科医院和广州市肝病医院收治12例结核病人服抗结核药后出现严重的过敏反应后的临床表现、实验室检查及预后情况。结果12例患者中男4例,女8例,年龄21～72岁,平均33.2岁。12例病人以门诊就诊为主,服药时间由9～60d,以发热、全身皮疹、肝功能严重损害为主要表现。经停抗结核药物并积极护肝、抗过敏等治疗后有9例治愈,1例转院,2例死亡。结论抗结核药物可发生严重不良反应,治疗过程中应提高警惕,出现过敏症状早期即应开始就诊和对症治疗,避免严重后果发生。Objective To improve the cognition of symptoms of allergic reactions caused by anti - TB medicine, and to reduce the delay in diagnosis and treatment. Methods A retrospective analysis on 12 cases with severe allergic reaction after the use of anti - TB medicine in Guangzhou Chest Hospital and Guangzhou hepatopathy hospital during June 2006 to December 2008. Result In all the cases, four were males while eight were females, with the age from twenty - one to seventy - two years old. All the cases consulted in outpatient department with a period of nine to sixty clays of use of anti - TB medicine. The main manifestation were fever, rash and abnormality of liver function. After termination of use of the anti - TB medicine, together with anti - allergic and liver - protection treatment, nine cases recovered, one case left the hospital without doctor＇ permission, but two died. Conclusion Doctors should be aware of the severe side effect of anti -TB drugs and patients should be advised to consult the doctor immediately while they have symptoms as described in this article. Prognosis might be fine due to early treatment, otherwise is bad.

关 键 词：抗结核药 过敏反应 皮疹 药物性肝损 药物超敏综合征 

分 类 号：R593.1[医药卫生—内科学] R978.3[医药卫生—临床医学]