高立体选择性地合成薄荷基溴和新薄荷基溴  

Synthesis of Menthyl Bromide and Neomenthyl Bromide by Highly Stereoselective Transformations

作　　者：欧阳歆[1] 张祚[1] 阳年发[1] 

机构地区：[1]湘潭大学化学学院环境友好化学与应用省部共建教育部重点实验室,湘潭411105

出　　处：《有机化学》2010年第1期120-123,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20772102);教育部博士点专项科研基金(No.20060530002)资助项目

摘　　要：薄荷基溴和新薄荷基溴是一类非常有用的不对称合成中间体.以L-薄荷醇为原料,通过与不同的溴化剂反应高立体选择性地得到薄荷基溴和和新薄荷基溴.当L-薄荷醇与盐酸和无水溴化锌反应时高立体选择性地得到薄荷基溴,当L-薄荷醇与三溴化磷反应时高立体选择性地得到新薄荷基溴.Menthyl bromide and neomenthyl bromide were synthesized from L-menthol via highly stereoselective bromination reactions. When a mixture of concentrated hydrobromic acid and anhydrous zinc bromide wasused as the brominating agent, menthyl bromide was stereoselectively formed. Neomenthyl bromide was highly stereoselectively obtained in the circumstance of using phosphorus tribromide as a brominating agent.

关 键 词：L-薄荷醇 薄荷基溴 新薄荷基溴 高立体选择性转变 

分 类 号：O621.3[理学—有机化学]