清胆胶囊对胆色素结石豚鼠胆汁中CRP及黏蛋白含量的影响  

Effects of Qingdan Capsule on C- Reactive Protein and Mucin in Bile in Model Guinea-pigs with Pigment Gallstones

作　　者：梁晓强[1] 章学林[2] 张静喆[2] 顾宏刚[2] 

机构地区：[1]上海中医药大学附属龙华医院中医外科研究所,上海200032 [2]上海中医药大学附属龙华医院普外科,上海200032

出　　处：《辽宁中医药大学学报》2010年第2期43-45,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：上海市重点学科资助课题(T0304);上海市医学领军人才资助课题(LJ06048);上海市教育委员会科研创新项目(09YZ131)

摘　　要：目的:观察清胆胶囊对胆色素结石豚鼠胆汁中CRP及黏蛋白含量的影响。方法:应用雄性豚鼠建立胆色素结石模型,观察清胆胶囊对其成石率、胆囊容积、胆汁中黏蛋白及C反应蛋白等指标的影响。结果:清胆胶囊组成石率显著降低(P<0.01),胆囊容积明显减小(P<0.05),胆汁中黏蛋白及C反应蛋白明显降低(P<0.05)。结论:清胆胶囊可降低成石胆汁中黏蛋白、C反应蛋白含量,从而发挥逆转成石胆汁及降低结石成石率的作用。Objective：To observe the effects of Qingdan capsule （QDJN） on on C- reactive protein and mucin in bile in model guinea-pigs with pigment gallstones.Methods：Animal model of pigment gallstones was reproduced in male guinea-pigs by hypodermic injection of lincomycin. And then we observed the rate of stone formation,gallbladder volume,mucin and C- reactive protein in bile between three groups. Results：Compared to model group,the rates of stone formation in QDJN group were significantly decreased （P0.01）,and gallbladder volume in QDJN group was significantly decreased（P0.05）.Meanwhile mucin and C- reactive protein content of bile in QDJN group was also significantly decreased（P0.05）. Conclusion：QDJN has good effects on model guinea-pigs with pigment gallstones in reversing the lithogenesity of bile by reducing the content of mucin and C- reactive protein in bile.

关 键 词：清胆胶囊 胆色素结石 豚鼠 

分 类 号：R256.4[医药卫生—中医内科学]