川芎嗪与自体骨膜植入预防椎板切除术后硬膜外粘连的实验研究  

Prevention of Eperidural Fibrosis and Adhesion after Laminectomy with Tetramethylpyrazine and Autogenous Periosteum Graft

作　　者：陈立科[1] 徐秋香[1] 孟国成[1] 李强[1] 吴波[1] 

机构地区：[1]湖南中医药大学临床医学院,湖南长沙市410007

出　　处：《中国康复理论与实践》2010年第1期32-34,F0003,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：湖南省自然科学基金资助课题(07JJ6048)

摘　　要：目的观察椎板切除术后用川芎嗪并在椎板缺损处植入自体骨膜预防硬膜外粘连的效果。方法48只SD大鼠随机分成A、B、C、D4组,制作L2板损伤模型。A组硬膜外涂布生理盐水,B组硬膜外涂布川芎嗪,C组硬膜外覆盖自体骨膜,D组硬膜外涂布川芎嗪的同时加自体骨膜覆盖。术后12周对椎板切除部位进行大体观察、组织学观察、生化检查比较组间瘢痕形成和粘连情况。结果B、C、D组的改良Rydell-Balazs粘连韧度评分、胶原含量、改良Nussvuaum组织学评分均明显优于A组(P<0.01),D组优于B组与C组(P<0.05)。结论联合运用川芎嗪和自体骨膜能有效预防硬膜外瘢痕粘连和形成,比单独应用川芎嗪和自体骨膜预防效果好。Objective To study the effect of tetramethylpyrazine cooperated with autogenous periosteum graft on fibrous scar formation in the epidural space after laminectomy. Methods 48 SD rats were divided randomly into 4 groups. Laminectomy was performed in lumbar 2 segment, and the exposed duras were covered with saline solution （group A）, tetramethylpyrazine （group B）, autogenous periosteum （group C）, and tetramethylpyrazine and autogenous periosteum （group D） respectively. 12 weeks postoperatively, they were evaluated with the gross and histopathological observation, biochemistry examination. Results The assessment of Rydell-Balazs and Nussbaum＇s Criterion of group B, C, D were obviously better than that of group A （P〈0. 01）, and that of group D was superior to group B and C （P〈0.05）, no significant difference between group B and C （P〉0. 05）. Conclusion Tetrameth- ylpyrazine cooperated with autogenous periosteum graft has a better effect on prevention peridural adhesion after laminectomy.

关 键 词：椎板切除术 硬膜 粘连 川芎嗪 自体骨膜植入 

分 类 号：R681.5[医药卫生—骨科学]