慢性乙型肝炎患者肝组织病理学分析  

Pathological and clinical analysis of liver biopsies in patients with chronic hepatitis B

作　　者：钮志林[1] 高胜利[1] 俞净[1] 徐密琴[1] 沈燕[1] 叶扬[1] 谭友文 

机构地区：[1]南通大学附属吴江医院感染病科,江苏省吴江市215200 [2]江苏省镇江市第三人民医院

出　　处：《实用肝脏病杂志》2010年第1期26-28,共3页Journal of Practical Hepatology

基　　金：江苏省吴江市科技局社会发展课题项目(WS200805)

摘　　要：目的探讨慢性乙型肝炎患者肝组织病理学与临床血生化指标的相关性。方法对252例慢性乙型肝炎患者肝穿活组织病理学检查结果与血清HBVDNA、肝功能等血生化指标进行统计学分析。结果肝组织炎症活动度与纤维化分期无明显的相关性(rs=-0.132,P=0.579);肝组织G4期患者血清ALT和PT水平明显高于G1期患者(P<O.05);血清HBVDNA水平与肝组织炎性活动度和纤维化程度无明显的相关性(P>0.01)。结论肝组织活检在肝脏病情评估中的作用是其它检查所不能代替的。Objective To investigate the relationship among serum HBV DNA,ALT,ALB,PT levels and liver tissue injuries in patients with chronic hepatitis B. Methods Routine biochemical liver function tests and serum HBV DNA levels were assayed in 252 patients with chronic hepatitis B,and the liver biopsies were performed and the grading and staging of the liver were routinely obtained. Results There was not obvious correlation between the inflammatory grading and fibrotic staging;Serum ALT and PT in patients with G4 were significantly higher than in with G1 ;Serum HBV DNA levels was not correlated with histological activity index or firbosis. Conclusion Liver biopsy still plays an unique role in judging the pathogenetic condition of liver in patients with chronic hepatitis B.

关 键 词：慢性乙型肝炎 HBV DNA 肝组织病理 

分 类 号：R512.62[医药卫生—内科学] R446.112[医药卫生—临床医学]