异甘草酸镁治疗慢性乙型肝炎临床疗效观察  

Clinical observation of magnesium isoglycyrrhizinate in the treatment of patients with chronic hepatitis B

作　　者：吴贻琛[1,2] 李秋贞[3] 刘鸿凌[2] 游绍莉[2] 辛绍杰[2] 

机构地区：[1]解放军总医院军医进修学院,北京市100853 [2]北京市解放军第302医院感染三科 [3]甘肃省金昌县金川集团公司职工医院

出　　处：《实用肝脏病杂志》2010年第1期34-36,共3页Journal of Practical Hepatology

摘　　要：目的观察异甘草酸镁注射液治疗慢性乙型肝炎的临床疗效。方法治疗组81例给予异甘草酸镁注射液150mg加入5%葡萄糖注射液中静脉滴注,对照组65例给予复方甘草酸苷注射液80ml加入5%葡萄糖注射液中静脉滴注,1次/日,治疗4周。观察症状、体征、肝功能变化及不良反应。结果两组患者的症状、体征均有明显改善;治疗组ALT、AST、TBIL复常率分别为92.6%、88.9%和87.7%,对照组则分别为90.8%、86.2%和83.1%,两组无明显差异;两组肝功能指标均有明显改善,治疗组ALT的恢复速度明显优于对照组,平均复常时间为17.0±10.5天,而对照组为24.7±13.7天。在本研究中,治疗组未发生明显的不良反应,而对照组发生2例不良反应。结论异甘草酸镁注射液可明显改善慢性乙型肝炎患者的临床症状和肝功能指标,临床应用安全有效。Objective To observe the clinical efficacy of magnesium isoglycyrrhizinate in the treatment of patients with chronic hepatitis B. Methods The 81 patients with chronic hepatitis B were treated with 150mg magnesium isoglycyrrhizinate and 65 were treated with 80ml compound isoglycyrrhizinate for 4 weeks. Symptoms, signs and hepatic function tests were observed. Results The level of ALT dropped more rapidly in magnesium isoglycyrrhizinate-treated patients than that in control group;There was no obvious side effects in magnesium isoglycyrrhizinate group,while there was 2 cases with side effects in control group. Conclusions Clinic symptom and liver function tests improve after treatment with magnesium isoglycyrrhizinate in patients with chronic hepatitis B.

关 键 词：慢性乙型肝炎 异甘草酸镁 复方甘草酸苷 治疗 

分 类 号：R512.62[医药卫生—内科学]