纳洛酮与氨茶碱联合治疗早产儿呼吸暂停疗效观察  

Curative effect of combination application of naloxone and aminophyUine in treatment of apnea neonatorum： analysis of 22 cases

作　　者：王东辉[1] 鲁丽[1] 韩桂珍[1] 张葳[2] 

机构地区：[1]吉林油田总医院儿科,松原市138006 [2]吉林省通榆县中医院急诊科

出　　处：《中国急救复苏与灾害医学杂志》2010年第1期28-29,43,共3页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的观察纳洛酮与氨茶碱联合应用治疗早产儿呼吸暂停的临床效果。方法22例患儿随机分为两组，治疗组12例在应用纳洛酮的基础上加用氨茶碱，对照组10例单用氨茶碱，两组各用3-5d，观察两组的临床效果。结果纳洛酬与氨茶碱治疗组：显效7例，显效率58％（7／12）；有效4例，有效率33％（4／12）；总有效率92％（11／12）。氨茶碱对照组：显效4例，显效率40％（4／10）；有效3例，有效率30％（3／10）；总有效率70％（7／10）。纳洛酮与氨茶碱治疗组的总有效率显著高于氨茶碱对照组（P〈0．01）。结论氨茶碱和纳洛酮联合应用治疗早产儿呼吸暂停比单用氨茶碱效果好，值得临床推广。Objective To investigate the curative effect of combination application of naloxone and aminophylline in treatment of apnea neonatorum. Methods Twenty-two newborns with apnea neonatorum, were randomly divided into 2 groups： combination application of naloxone and aminophylline group （n=12）, 7 male and 5 female, undergoing intravenous injection of naloxone at the dosage of 0.1 mg/kg as the first-time loading dose and then continuous intravenous injection at the speed of 0.01 mg/kg/h, and oral administration of aminophylline at the dosage of 5 mg/kg as the first-time loading dose and then 2.5 mg/kg every 12 hours as the maintenance dose for 3-5 days, and aminophylline control group （n=10）, 6 male and 4 female, given aminophylline at the dosage of 5 mg/kg as the first-time loading dose and then 2.5 mg/kg per 12 hours as maintenance dose for 3-5 days. The heart beat and respiration were observed. Results The general effective rate of the combination application group was 92% （11/12）, significantly higher than that of the aminophylline control group （70%, 7/10, P〈0.01）. Conclusion The combinatioh application of naloxone and aminophylline is effective in treatment of apnea neonatornm.

关 键 词：纳洛酮 氨茶碱 呼吸暂停 早产儿 

分 类 号：Q722.6[生物学—分子生物学]