通心络胶囊对缺血性脑血管病患者血清C反应蛋白及颈动脉斑块的影响  

EFFECTS OF TONGXINLUO CAPSULE ON SERUM C-REACTIVE PROTEIN AND CAROTID PLAQUE OF PATIENTS WITH ISCHEMIC VASCULAR DISEASE

作　　者：李勇[1] 胡蓓蕾[1] 管璇[1] 代允义[1] 王小同[1] 宋兴伟[1] 

机构地区：[1]温州医学院第二附属医院,温州325000

出　　处：《中国中医药科技》2010年第1期10-11,共2页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:观察通心络胶囊对缺血性脑血管病患者C反应蛋白(C-reactive protein,CRP)及颈动脉斑块的影响。方法:将87例患者随机分为通心络组(43例)和立普妥组(44例),治疗3月后,观察两组患者总胆固醇、低密度胆固醇、甘油三酯、CRP及颈动脉内中膜厚度和斑块大小的变化。结果:两组患者治疗后血CRP明显下降(P<0.05),颈动脉内中膜厚度明显变薄(P<0.05),斑块明显缩小(P<0.05)。通心络组治疗后总胆固醇、低密度胆固醇和甘油三酯虽有下降,但差异无显著意义(P>0.05)。立普妥组治疗后,总胆固醇、低密度胆固醇明显下降,与治疗前比较有显著性差异(P<0.05)。治疗后两组组间比较,除总胆固醇和低密度胆固醇下降有显著性差异(P<0.05),余指标无显著性差异。结论:通心络抗颈动脉粥样斑块作用机制可能与降低血清CRP有关。Objective: To observe the effects of tongxinluo capsule on C-reactive protein and carotid plaque in patients with ischemic vascular disease.Methods: 87 cases with ischemic vascular disease were divided into tongxinluo and western medicine groups, observing the changes of serum TC,TG,LDL,CRP and determining the intima-media thickness of carotid and plaques area after treated 3 monthes.Results: CRP level of two groups was lowered significantly, intima-media thickness of carotid was thinner than that before treated, and plaques area got smaller , there was no difference between the tongxinluo capsule and western medicine groups.The blood lipid level was lowered in tongxinluo group, but the changes were no singnificant; western medicine(lipitor) could obviously lowered the blood lipid level, there was difference between the tonxinluo capsule and western medicine groups.Conclusion: The effects of tongxinluo capsule on carotid plaque in patients with ischemic vascular disease was related to lowering the serum CRP level.

关 键 词：动脉硬化/中医药疗法 通心络/治疗应用 颈动脉 人类 

分 类 号：R277.7[医药卫生—中医学]