老年患者术后认知功能障碍与血清S100β及神经元特异性烯醇化酶的关系  

The relationship between serum S100β, neuron-specific enolase and postoperative cognitive dysfunction in the elderly

作　　者：尹光明[1] 姚尚龙[1] 梁卫东[2] 

机构地区：[1]华中科技大学同济医学院协和医院, 武汉430022 [2]济宁医学院附属医院

出　　处：《中华行为医学与脑科学杂志》2010年第1期42-43,共2页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探讨血清S100β和神经元特异性烯醇化酶（NSE）与老年人发生术后认知功能障碍（POCD）的关系。方法使用中文版成人智力量表（WAIS）和韦氏记忆量表（WMS）对560例行择期手术的老年患者进行术前1天和术后1周的神经、精神功能测试，对439例未发生术后认知功能障碍的老年人（对照组）和121例POCD患者进行麻醉前和手术结束及术后6h、24h血清S100β和NSE的含量检测。结果麻醉前POCD患者血清S100β和NSE的含量与对照组无明显差异（P〉0．05）；术毕两组患者血清S100β和NSE的含量为最高[分别为（0．68±0．32）μg/L，（1．28±0．51）μg/L，P〈0．05；（13．51±6．23）μg/L，（22．08±10．11）μg/L，P〈0．05]；术后24h对照组患者血清S10013和NSE的含量已恢复至麻醉前水平[分别为（0．50±0．11）μg/L，（10．90±2．93）μg/L]，而POCD患者血清S10013和NSE的含量仍维持较高水平[分别为（0．98±0．27）μg/L，（16．44±6．83）μg/L]，两组比较差异有显著性（P〈0．05）。POCD组血清S100β和NSE与认知障碍各项指标呈相关性（r=0．367～0．786，P〈0．05）。结论血清S100β和NSE的含量与老年患者POCD发生存在关联性。Objective To explore the relationship between S100β, neuron-specific enolase（NSE） and postoperative cognitive dysfunction（POCD） in the elderly. Methods Cognitive function was evaluated using a battery of nine neuro- psychological tests before operation,at one week after operation. The old people were divided into POCD group（ n= 121 ） and normal group（n=439）. Their S100β and NSE levels in all group were detected by enzyme linked immunosorhent assay（ELISA） before anesthesia,at the end of surgery and 6h,24h after operation. Meanwhile relativity between S100βand NSE levels and factors of postoperative cognitive dysfunction were analyzed. Results S100β and NSE levels increased significantly at the end of surgery in both groups,but the levels in normal group were significantly lower than those in POCD group at the same stage（P〈0.05）. S100β and NSE levels were obviously relative to POCD. Conclusion S100β and NSE levels have close correlation with POCD in the elderly.

关 键 词：认知障碍 手术后并发症 S100Β蛋白 神经元特异性烯醇化酶 

分 类 号：R614[医药卫生—麻醉学]