两种胰岛素强化治疗方案对磺脲类药物继发失效的2型糖尿病患者的短期疗效比较  

Comparison of therapeutic effects of short-term intensive insulin treatments in type 2 diabetic patients

作　　者：王晓书[1] 张维明[1] 

机构地区：[1]广安市人民医院内分泌科,四川广安638000

出　　处：《西部医学》2010年第2期242-244,共3页Medical Journal of West China

摘　　要：目的评价两种胰岛素强化治疗方案对口服磺脲类药物继发失效的2型糖尿病患者疗效。方法将64例口服磺脲类药物继发失效的2型糖尿病患者随机分为A组(给予每天三次诺和锐+睡前一次甘精胰岛素皮下注射)和B组(给予诺和锐30每天三次皮下注射),分别观察两组患者治疗后血糖达标的时间、血脂的改善、水肿发生率、体重增加程度、胰岛素用量、低血糖发生频率及医疗费用情况。结果两组治疗均能有效改善高血糖状态,改善脂代谢紊乱。但甘精胰岛素组血糖达标所需时间更短[(5.28±0.62)d vs(6.02±0.78)d,P<0.05]。结论磺脲类药物继发失效的2型糖尿病患者改用胰岛素强化治疗均能获得较好的疗效,使用甘精胰岛素血糖达标更快,但医疗费用偏高。Objective To investigate the Ctherapeutic effects between two kinds of short-term intensive insulin treatments in type 2 diabetic patients without efficacy of sulphonylureas. Methods 64 patients with Type 2 diabetes mellitus （T2DM） without efficacy of sulphonylureas were divided into two groups. A group （n=32） was injected with aspart before each meal and glargine before sleep. B group （n=32） was injected aspart30 three times a day. The time when the blood glucose controlled, improvement of lipid metabolism, the rate of edema, the weight of patients, the amount of insulin, the rate of hypoglycemia and the cost of the treatment were observed. Result Both of the treatment improved the high blood glucose and disturbance of lipid metabolism. The time when control blood glucose of A group was shorter than that in B group （5.28±0.62 vs 6.02±0. 78, P〈0.05）. Conclusion Intensive insulin treatment could obtain better curative effect in type 2 diabetic patients who lose efficacy of sulphonylureas.

关 键 词：磺脲类降糖药 继发失效 2型糖尿病 胰岛素强化治疗 

分 类 号：R587.1[医药卫生—内分泌]