DXA测量骨密度的精确度评估  

Evaluation of the precision error on measurements of bone mineral density with dual-energy X-ray absorptiometry

作　　者：郭郡浩[1] 施慧鹏[2] 赵燕玲[3] 

机构地区：[1]南京军区南京总医院中西医结合科,江苏南京210002 [2]上海交通大学附属第六人民医院骨科,上海200233 [3]北京和睦家医院妇产科,北京100029

出　　处：《徐州医学院学报》2010年第1期40-44,共5页Acta Academiae Medicinae Xuzhou

摘　　要：目的分析双能X线吸收测定术(dual-energy X-ray absorptiometry,DXA)测量骨密度(bone mineraldensity,BMD)的最小有意义变化(least significant change,LSC)。方法测量30名受检者腰椎和髋部BMD,连续测量2次,计算其精确度误差、最小有意义变化,预计随访间隔时间。结果L1-L4、L2-L4、左全髋部、右全髋部的精确度误差相对较低,标准差的均方根(RMS-SD)分别为0.006、0.007、0.006、0.007 g/cm2,最小有意义变化(LSC-SD)分别为0.016、0.018、0.018、0.019 g/cm2;变异系数的均方根(RMS-CV)分别为0.005、0.007、0.006、0.007,最小有意义变化(LSC-CV)分别为0.015、0.020、0.018、0.020。LSC-SD、LSC-CV的变异系数分别为0.238、0.356。预计随访间隔时间随着感兴趣区精确度误差的增加而延长。结论DXA测量骨密度的精确度误差较小,感兴趣区首选L1-L4、L2-L4、全髋部为宜,感兴趣区的精确度误差越大则预计随访时间越长。Objective To analyze the least significant change （LSC） of bone mineral density （BMD） measurement with dual energy X - ray absorptiometry （DXA）. Methods 30 subjects had their BMD in the lumbar vertebrae and hip measured twice consecutively. The precision error （PE）, LSC and monitoring time interval （MTI） were calculated. Re- suits In the region of interest （ROI） of L1 - L4, L2 - L4, left - hip and right - hip, the root mean square standard de- viation （ RMS - SD） was 0. 006, 0. 007, 0. 006 and 0. 007 g/cm2, respectively; LSC - SD was 0. 016, 0. 018, 0.018 and O. 019 g/cm2, respectively ; the root mean square coefficient of variation （ RMS - CV） was 0. 005, O. 007, O. 006 and 0. 007, respectively; LSC - CV was 0. 015, 0.020, 0. 018 and 0. 020, respectively. The CV of LSC - SD and LSC - CV was 0. 238 and 0. 356 respectively. The monitoring time interval was prolonged with the increase of the PE in homologous ROI. Conclusion PE of BND measurements with DXA is relatively small. It is preferable to select the ROI of LL - L4, L2 - L4 and total hip. The greater the PE in homologous ROI, the longer the monitoring time interval will be.

关 键 词：骨密度 骨质疏松症 精确度误差 最小有意义变化 预计随访间隔时间 双能X线吸收法 

分 类 号：R681[医药卫生—骨科学] R195.1[医药卫生—外科学]