电纺聚-L-乳酸/β-磷酸三钙复合物纳米纤维膜  

Electrospun poly-L-lactic acid/β-tricalcium phosphate composite nanofiber membranes

作　　者：孙复钱[1] 姚琛[1] 李新松[1] 范凯红[2] 浦跃朴[2] 

机构地区：[1]东南大学化学化工学院,南京210018 [2]东南大学公共卫生学院,南京210018

出　　处：《东南大学学报（自然科学版）》2010年第1期213-217,共5页Journal of Southeast University：Natural Science Edition

基　　金：国家自然科学基金资助项目(50673019)

摘　　要：利用静电纺丝法制备了生物可吸收聚-L-乳酸(PLLA)/β-磷酸三钙(β-TCP)复合物纳米纤维膜.采用扫描电子显微镜(SEM)、场发射扫描电子显微镜(FESEM)等手段研究了复合物纳米纤维膜的结构和形态,详细探讨电纺工艺条件对制备PLLA/β-TCP复合物纳米纤维的形态影响.通过拉伸力学测试、噻唑蓝比色法(MTT)对复合物纳米纤维膜的力学性能和体外细胞相容性作了进一步研究.结果表明,PLLA/β-TCP复合物纳米纤维的几何结构与电纺条件有关,随着聚合物溶液浓度增加、溶液流速增大,纤维直径有不同程度的增大;复合物纳米纤维膜的拉伸强度和杨氏模量随β-TCP的含量增加而下降;复合物纳米纤维膜对L-929细胞系无细胞毒性,显示良好的细胞相容性.Poly （ L-lactic acid）/β-tricalcium phosphate （PLLA/β-TCP） composite nanofiber membranes were prepared by electrospinning. The structure and morphology of the composite nanofiber membranes were studied by scanning electron microscopy （SEM） and field emission scanning electron microscopy （FESEM）. And mechanical properties of composite nanofiber membranes were characterized by tensile tester. A primary study of the cellular compatibility of the composite nanofiber membranes was carried out by MTT （methylthiazolyldiphenyl-tetrazolium bromide） assay. The results show that the geometrical structures of the composite nanofibers depend on processing parame- ters such as PLLA concentration. With the increasing of PLLA concentration and feed rate, the di- ameters of the fibers increase. The tensile strength and Young＇s modulus of composite nanofiber membranes are lowered with increasing the content of β-TCP. Electrospun PLLA/β-TCP composite nanofibers show good cytocompatibility to L-929 cells according to MTT assay.

关 键 词：电纺 纳米纤维膜 聚-L-乳酸 Β-磷酸三钙 复合物 

分 类 号：TQ342.94[化学工程—化纤工业]