荧光图像早期癌症诊断仪的临床应用研究  

Study of Clinical Application on Autofluorescence Imaging in the Diagnosis of Early Cancer

作　　者：叶衍铭[1] 萧树东[1] 戈之诤[1] 郑家骠[1] 夏敬芳[1] 姜智敏[1] 

机构地区：[1]上海市消化疾病研究所内镜荧光图像研究课题组,上海市200001

出　　处：《中国医疗器械杂志》2010年第1期62-65,共4页Chinese Journal of Medical Instrumentation

摘　　要：论述以自发荧光技术为基础的荧光图像诊断的原理和产生机制,应用荧光光谱比值的阈值定则这个可量化、客观和可靠的检测方法能提供消化道粘膜直观的自发荧光图像,根据图像颜色的差异能够快速地找到可疑病灶,在临床应用的消化道肿瘤诊断研究中取得了敏感性、特异性、诊断率分别为94.0%、95.5%和94.8%的效果,具有很高的应用价值。The mechanism and principles of autofluorescence imaging based on autofluorescence technique are reported. The threshold value of fluorescence spectrum ratio applied can be quantitative and objective and the reliable measurement method that may provide intuitive method of autofluorescence imaging in the gut mucosa. The suspected lesion may be found rapidly according to the imaging color difference, therefore the results of clinical study of the digestive tract cancer diagnosis indicated that the sensitivity, specificity, and diagnostic accuracy were 94%, 95.5% and 94.8% respectively, and it has very high value in clinical application.

关 键 词：自发荧光 荧光图像 消化道肿瘤/诊断 

分 类 号：O657.31[理学—分析化学]