通心络胶囊对不稳定性心绞痛患者血清高敏C反应蛋白、肿瘤坏死因子-α的影响  

Effcet of Tongxinluo capsul on hs-CRP、TNF-a in patients with angina pectoris

作　　者：过晶[1] 陈风[1] 过云峰[1] 高长征[1] 

机构地区：[1]苏州大学附属无锡第四人民医院心内科,江苏无锡214062

出　　处：《中国微循环》2009年第6期535-537,共3页Journal of Chinese Microcirculation

摘　　要：目的观察冠心病心绞痛患者通心络胶囊治疗前后血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)的变化,探讨通心络胶囊的干预机制。方法将61例不稳定性心绞痛(UA)患者随机分为对照组(31例)和治疗组(30例),对照组为常规药物治疗,治疗组在此基础上加用通心络胶囊。4周后,用酶联免疫吸附法(ELISA)测定两组患者治疗前后血清hs-CRP、TNF-α表达水平。结果与治疗前比较,两组患者治疗后血清hs-CRP、TNF-α水平下降(P<0.01),治疗组较对照组下降更为明显(P<0.01)。结论通心络胶囊可显著抑制炎症反应,降低hs-CRP、TNF-α水平,起到对心脏的保护作用。Objective To investigate the protective effect and possible mechanisms of Tongxinluo capsul on angina pectoris. Methods Sixty-one patients with unstable angina pectoris(UA) were randomly divided into the control group(n=31) treated by conventional therapy and the treatment group(n=30) treated by Tongxinluo capsule on this basis. 4 weeks later,serum high sensitive C-reactive protein(hs-CRP) and tumor necrosis factor-a(TNF-a) were determined with ELISA before and after treatment. Results The levels of hs-CRP,TNF-a were significantly lower in both groups after treatment than those before treatment(P<0.01),and the decrement in the treatment group was more significant than that in the control group(P<0.01). Conclusion Tongxinluo casule could inhibit the development of angina pectoris through down-regulating the expresssion of serum TNF-α,decreasing serum hs-CRP concentration and inhibiting inflammatory reaction.

关 键 词：通心络胶囊 冠心病 心绞痛 高敏C反应蛋白 肿瘤坏死因子-Α 

分 类 号：R541.4[医药卫生—心血管疾病]