1993～1996年中国部分地区腹裂畸形的患病率分析  

Prevalence of gastroschisis in 27 counties/cities in China,1993-1996

作　　者：方玉霞[1] 李智文[1] 王太梅[2] 叶荣伟[1] 刘建蒙[1] 任爱国[1] 

机构地区：[1]北京大学生育健康研究所,北京100191 [2]北京大学第三临床医院儿科

出　　处：《中国生育健康杂志》2009年第6期341-345,共5页Chinese Journal of Reproductive Health

摘　　要：目的分析中国河北、江苏和浙江省腹裂畸形的患病率状况。方法采用以人群为基础的出生缺陷监测方法,监测河北、江苏和浙江省27个县市1993年至1996年间所有孕20周及以上至出生后42 d内的胎婴儿,分析腹裂畸形的患病率状况。结果河北、江苏、浙江省共发生腹裂畸形119例,腹裂的患病率平均为1.84/万,其波动范围为1.01/万～4.26/万;河北省腹裂畸形的患病率(3.91/万)高于江苏省(1.46/万)及浙江省(1.47/万)的平均水平;北方地区腹裂畸形的患病率(3.91/万)高于南方(1.46/万);腹裂患儿的死胎死产率为52.94%,复合腹裂畸形的死胎死产率(80.00%)高于单纯腹裂畸形(36.49%),差异均有统计学意义(P<0.05);农村地区腹裂畸形的患病率为1.94/万,城市为1.39/万;男性腹裂患儿的患病率为1.75/万,女性为1.62/万,差异均无统计学意义(P>0.05);河北、江苏及浙江省各年度腹裂畸形的患病率无显著变化;腹裂畸形患儿37.82%(45/119)为伴有其它畸形的复合腹裂。结论腹裂畸形的患病率北方地区高于南方,复合腹裂畸形的死胎死产率明显高于单纯腹裂畸形;城乡、性别及各年份之间患病率无明显差异。Objective To characterize the distribution of gastrosehisis in 27 counties/cities in Hebei, Jiangsu and Zhejiang provinces in China, 1993-1996. Methods Data were collected from a popula- tion-based birth defects surveillance system in 27 counties/cities in three provinces, Hebei, Jiangsu and Zhejiang, 1993-1996. All births at least 20 weeks＇gestation （fetal deaths, still births and live births） were included. Results The average prevalence of gastroschisis was 1.84 per 10 000 births, ranging from 1.01 per 10 000 births to 4. 26 per 10 000 births. The prevalence was 3.91 per 10 000 births in Hebei, 1.46 per 10 000 births in Jiangsu, and 1.47 per 10 000 births in Zhejiang, respectively. Rural areas had similar prevalence （1.94 per 10 000 births） to urban areas （1.39 per 10 000 births）. The prevalence was similar for males （ 1.75 per 10 000 births） and for females （ 1.62 per 10 000 births）. No significant change in the prevalence was noted during the four-year period in any of the three provinces. Conclusion The prevalence of gastroschisis in Hebei province is significantly higher than that in Jiangsu and Zhejiang provinces. No temporal trend is observed from 1993 through 1996 in Hebei, Zhejiang, or Jiangsu province. No significant difference in the prevalence is noted between male and female, and between the rural and the urban areas.

关 键 词：胎儿 婴儿 腹裂 畸形 患病率 

分 类 号：R726.2[医药卫生—儿科]