谷氨酰胺对老年营养不良患者免疫功能的影响  

Effects of glutamine on immune function in elderly patients with malnutrition

作　　者：易仁亮[1] 江亚文[1] 

机构地区：[1]广州军区广州总医院老年病一科,510010

出　　处：《中华临床营养杂志》2009年第6期343-345,共3页Chinese Journal of Clinical Nutrition

摘　　要：目的观察谷氨酰胺对老年营养不良患者免疫功能的影响。方法将24例老年营养不良患者随机分成谷氨酰胺组和对照组（每组12例），给予连续7d等氮、等热量的肠内营养，其中谷氨酰胺组给予谷氨酰胺颗粒7．5g每日3次口服。比较两组患者治疗前后外周静脉血IgG、IgA、IgM含量和CD3、CD4、CD8百分比及CIM／CD8比值的变化。结果谷氨酰胺组患者外周静脉血IgG、IgA含量和CD3、CD4百分比及CD4／CD8比值均明显高于对照组（P〈0．05或P〈0．01）。结论谷氨酰胺能改善老年营养不良患者的免疫功能，促进康复。Objective To evaluate the effects of glutamine on immune function in elderly patients with malnutrition. Methods Twenty-four elderly patients with malnutrition were equally randomized divided into glutamine group and control group. Patients in both two groups were administered with enteral nutrition containing equal nitrogen and calorics for consecutively 7 days. In the glutamine group, patients were also supplied with oral glutamine （7.5g rid）. Changes of plasma IgG, IgA, and IgM levels, percentages of T-lymphocyte subsets （CD3, CD4, CDS） , and CD4/CD8 ratio were determined before and after treatment. Results Plasma IgG and IgA levels, percentages of CD3 and CD4, and CD4/CD8 ratio were signifieandy higher in glutamine group than in control group （P 〈 0.05 or P 〈 0.01 ）. Conclusion Glutamine can improve the immune function in elderly patients with malnutrition and promote their recovery.

关 键 词：谷氨酰胺 老年 免疫功能 

分 类 号：R459.3[医药卫生—治疗学]