动态亚低温治疗重型颅脑损伤  

Dynamic mild hypothermia on patients with severe head injury

作　　者：冯金周[1] 钱骏[1] 刘发健[1] 龙武军[1] 

机构地区：[1]四川省医学科学院、四川省人民医院城东病区神经外科,成都610101

出　　处：《中华神经医学杂志》2010年第2期187-189,共3页Chinese Journal of Neuromedicine

摘　　要：目的探讨动态亚低温治疗重型颅脑损伤的临床疗效。方法选择自2003年1月至2009年5月四川省人民医院城东病区神经外科收治的重型颅脑损伤患者174例，采用随机数字表法分成动态亚低温组（A组）、亚低温短时程组（B组）及常温治疗组（C组），比较其临床疗效及并发症。结果A组有效率为84．48，死亡率为8．62％；B组有效率为67．24，死亡率为15．51％：C组有效率为48．27，死亡率为36．20％；3组有效率差异有统计学意义（P〈0．05）。总并发症3组比较差异无统计学意义（P〉0．05）。结论根据重型颅脑损伤患者个体化差异采取亚低温动态化治疗，能有效提高治疗有效率．且并发症不会增加。Objective To investigate the clinical effects of dynamic mild hypothermia on patients with severe brain injury. Methods One hundred and seventy-four patients with severe brain injury, admitted to our hospital from 2003 to 2009, were chosen and randomly assigned to mild hypothermia treatment group, short-term mild hypothermia treatment group and control group; their clinical outcomes and complications were recorded. Results The difference on effective rate of the 3 groups was significant （84.48%, 67.24%, 48.27%, respectively, P〈0.05）; the mortality in the 3 groups was 8.62%, 15.51%, 36.20%, respectively. No significant difference of complications was showed in the 3 groups （46.55%, 46.55% and 48.27%, respectively, P〉0.05）. Conclusion Dynamic mild hypothermia therapy can improve the outcomes of severe brain injury according to the patients＇ condition.

关 键 词：颅脑损伤 亚低温 动态化治疗 短时程 

分 类 号：R651.15[医药卫生—外科学]