肤康涂膜剂处方优选的实验研究  

Experimental Study of Formula Optimization for Fukang Plastics

作　　者：盛国荣[1] 

机构地区：[1]江苏省南通市皮肤病性病防治所,江苏南通226006

出　　处：《中国药业》2010年第4期17-19,共3页China Pharmaceuticals

基　　金：南通市指令性社会发展科技计划项目;项目编号:S2007026

摘　　要：目的筛选肤康涂膜剂处方的最佳药物用量。方法采用正交试验设计法,考察不同处方的肤康涂膜剂对实验性小鼠的镇痛作用和对豚鼠皮肤石膏样毛癣菌感染模型的治疗作用,根据考察数据设计最佳处方。结果最佳处方为1000mL肤康涂膜剂中含水杨酸30g,酮康唑20g,薄荷脑20g,氯霉素10g。结论正交试验设计法优选肤康涂膜剂的处方,方法可行,效果满意。Objective To screen the best formula for Fukang Plastics. Methods The orthogonal experiment was used to study the abirritation effect on rats and the treating effect on infection model caused by trichophyta gypseum. The best formula was designed according to the result of this study. Results The optimal formula was salicylic acid 30 g, ketoconazole 20 g, menthol 20 g, chloramghenicol 10 g per 1 000 mL. Conclusion The formula optimized by orthogonal experiment is reasonable with satisfactory effect.

关 键 词：正交设计 肤康涂膜剂 处方优选 镇痛试验 石膏样毛癣菌感染模型 

分 类 号：R285.5[医药卫生—中药学]