2型糖尿病踝肱指数和尿白蛋白肌酐比关系  

Clinical observation about relationship between ankle-brachial index and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus

作　　者：董林[1] 叶山东[1] 杨光伟[1] 

机构地区：[1]安徽医科大学附属省立医院内分泌科,合肥230001

出　　处：《安徽医学》2010年第1期18-19,共2页Anhui Medical Journal

基　　金：安徽省临床医学应用技术项目(2008B020)

摘　　要：目的观察2型糖尿病患者踝肱指数(ABI)和尿白蛋白肌酐比(尿ACR)关系。方法对487名2型糖尿病患者采用ES1000SPM多普勒血流探测仪测定ABI,并依据ABI分组,周围动脉病变(PAD)组(ABI<0.9),非血管病变组ABI≥0.9,同时检测所有患者尿ACR,进行组间比较,并对二者进行线性相关分析。结果ABI<0.9者72例,占14.78%,与非血管病变组比较,PAD组尿ACR异常率显著增高,P<0.01;相关分析显示,2型糖尿病患者ABI与尿ACR呈显著负相关(r=-0.327,P<0.01)。结论ABI和尿ACR检查可作为筛查2型糖尿病患者周围血管病变与糖尿病肾病的方法,二者存在一定的关联。Objective To investigate the relationship of ankle-brachial index（ABl） and the urinary albumin/creatinine ratio （urine ACR） in type 2 diabetics. Methods ABI was examined in the 487 patients with type 2 diabetes using ES 1000 SPM doppler flow detectors . All the patients were divided into peripheral arterial disease （PAD） group（ABI 〈0.9）and non-vascular lesion group（ ABI ≥ 0.9） acorrding the values of ABI. At the same time, urine ACR of all patients was tested with the fastin urinary sample. Results Among the 487 patients, 78 patients had PAD （ 14.78%）.Compared with the normal group, abnormal rate of urine ACR increased significantly in group PAD （P〈0.01）; Correlation analysis showed that UACR was negatively related to the ABI in type 2 diabetics （r=-0.327, P〈0.01）. Conclusion ABI and urine ACR can be used as indexes for screening peripheral arterial disease and diabetic nephropathy in patients with type 2 diabetes, respectively .There is a certain degree of correlation between the two index.

关 键 词：2型糖尿病 踝肱指数 尿白蛋白肌酐比 

分 类 号：R587.2[医药卫生—内分泌]