基于硼氢化钾-三氟化硼乙醚还原体系的3,4-二甲氧基苯乙胺合成新方法  

Synthesis of 3,4-Dimethoxy Phenethylamine Based on KBH_4/F_3B-Et_2O Reduction System

作　　者：李定中[1] 蔡安安[1] 魏建科[1] 游懿[1] 龚福春[1] 

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410004

出　　处：《广东化工》2010年第2期19-20,共2页Guangdong Chemical Industry

基　　金：湖南省科技计划资助项目(2009CK3069)

摘　　要：以邻苯二酚为原料,经醚化、Vilsmeier反应制得藜芦醛,收率95.2%,藜芦醛与硝基甲烷反应制得了3,4-二甲氧基苯基-β-硝基乙烯,收率高达93.6%,然后利用硼氢化钾-三氟化硼乙醚体系(KBH4/BF3-Et2O)催化还原3,4-二甲氧基苯基-β-硝基乙烯合成3,4-二甲氧基苯乙胺。该方法使用KBH4/F3B-Et2O还原体系,具有反应条件温和、后处理容易、产率较高等特点,适于工业化生产。Veratraldehyde was prepared from pyrocatechol by methylation and vilsmeier reaction with a yield of 95.2 %. 3,4-dimethoxyphenethylamine was synthesized from veratraldehyde by reaction with nitromethane and reduction with KBH4/BF3-Et2O system in two steps. The reaction was not only condition-facile and easy to dealing with product, but also plurinatality. So the process can be used in the industry.

关 键 词：KBH4/BF3-Et2O体系 3 4-二甲氧基苯乙胺 还原 

分 类 号：TQ[化学工程]