阿司匹林-壳聚糖缓释微球的制备和释药性能研究  

Preparation and Controlled Release Characteristic of Aspirin-loaded Chitosan Microspheres

作　　者：周莉[1] 吴奕光[1] 罗仲宽[1] 刘波[1] 廖传东[1] 张念[1] 

机构地区：[1]深圳大学化学与化工学院深圳市功能高分子重点实验室,广东深圳518060

出　　处：《广东化工》2010年第2期197-199,共3页Guangdong Chemical Industry

摘　　要：采用乳化交联法制备阿司匹林-壳聚糖缓释凝胶微球,通过透析实验检测微球的体外释放特性。应用正交实验设计,考察了壳聚糖浓度,搅拌速度,阿司匹林/壳聚糖质量比,交联时间对微球制备的影响。体外释放实验表明,壳聚糖微球前5个小时的释放符合SRP的释药行为。以5个小时的体外释放总量为指标进行直观分析,交联时间对5小时的体外释放总量影响最大。The preparation technique of aspirin-loaded chitosan microspheres and its release characteristic was investigated. Aspirin-loaded chitosan sustained-release gel microspheres were prepared via emulsion cross-linking technology. Dialysis method was used to determine the releasing characteristic of microspheres in vitro. The orthogonal experimental design was applied to review the preparation procedure by influence of chitosan concentration, stirred rate, mass ratio of aspirin/chitosan and emulsion cross-linking time. The results show that the release action of the aspirin-chitosan microspheres in the first five hours accorded with the action of sustained release preparation（SRP）. Through direct analysis of the total quantity of dialysis in vitro in five hours, cross-linking time was the most important influence factor.

关 键 词：阿司匹林 壳聚糖 缓释微球 乳化交联法 

分 类 号：TQ[化学工程]