紫外光谱净信号法测定酸性环境下复方磺胺甲噁唑片两个有效组分  

Fast determinations of two effective components in compound sulfamethoxazole tablet in acid condition by using net analyte signal of Uv

作　　者：张丹丹[1] 袁高林[1] 印洁红[1] 林菲菲[1] 鄂翔[1] 谢洪平[1] 

机构地区：[1]苏州大学药学院,江苏苏州215123

出　　处：《化学研究与应用》2010年第2期136-139,共4页Chemical Research and Application

基　　金：苏州大学优秀中青年学术带头人基金项目(R2317043)资助;国家大学生创新性实验计划项目资助

摘　　要：被分析组分的光谱净信号将正交于其它药物组分和辅料光谱所张成的光谱子空间，从而消除其它组分对被分析组分的光谱干扰，此净信号将与被分析组分的浓度成正比，据此建立了药物制剂分析的净信号方法。本文利用该方法研究了在酸性条件下紫外光谱测定复方磺胺甲曙唑片的两种有效成分磺胺甲嚼唑（SMZ）和甲氧苄啶（TMP）。SMZ和TMP的线性范围分别为0．48—7．84μg／mL（r=0.9981）和0．12-1．5tw／mL（r=0．9986）。平均回收率分别为99．5％和101．0％，RSD分别为1．87％和3．60％。本法简便、快速和准确。可用于酸性条件下复方磺胺甲嚼唑片中SMZ和TMP含量的快速、同时准确测定。Since the spectral net signal of the analyzed component was orthogonal to the spectral subspace spanned by the other drug spectra and the assistant ones,the spectral disturbance of the analyzed component should be eliminated, and then its spectral net signal should be directly proportional to its concentration. Based on the basic idea, the analyzed component of the drug was determined. This paper has studied the determinations of the two effective components sulfamethoxazole （SMZ） and trimethoprim （TMP） contained in compound sulfamethoxazule tablet by using ultraviolet spectroscopy. The linear ranges of SMZ and TMP were 0.48-7.84（g/mL（r =0.9981 ） and 0.12-1. 5μg/mL（ r =0. 9986）, the corresponding average recoveries were 99.5% and 101. 0% ,and the relative standard deviations were 1.87% and 3.60% ,respectively. The method was simple,fast and accurate. It could be used in acid condition to simultaneously determine SMZ and TMP in the compound sulfaraethoxazole tablet.

关 键 词：紫外光谱净信号 磺胺甲噁唑 甲氧苄啶 酸性环境. 

分 类 号：O657.32[理学—分析化学]