叶酸接枝聚乙二醇化壳聚糖衍生物的合成  

Synthesis of O-PEG-N-folate-chitosan derivatives

作　　者：陶凤[1] 席隆一[1] 邓胜伟[1] 余园园[1] 李瑛[1] 

机构地区：[1]四川大学化学学院,四川成都610064

出　　处：《化学研究与应用》2010年第2期182-185,共4页Chemical Research and Application

基　　金：四川大学学生科研训练计划项目资助

摘　　要：本文通过邻苯二甲酸酐保护壳聚糖的2-NH2,在壳聚糖的6-OH上引入聚乙二醇单甲醚。再经脱保护基团、2-NH2挂接叶酸,合成了叶酸接枝的聚乙二醇化壳聚糖。目标物用FT-IR,1HNMR,UV-Vis进行了表征。mPEG and folic acid were grafted into chitosan for potential gene carrier for tumor cells. N-phthaloyl chitosan was prepared for protected amino groups of chitosan, then N-phthaloyl chitosan was reacted with MPEG iodide and removed N-phthaloyl group subsequently. Finally, the folic acid was grafted to the amino group of chitosan and O-mPEG-N-folate-chitosan derivative was prepared. The structures of chitosan and its derivatives were characterized and confirmed by 1H NMR, FT-IR and UV-Vis spectroscopy. O-mPEG-N-folate-chitosan may be used as potential gene carrier for tumor cells.

关 键 词：壳聚糖 叶酸 聚乙二醇单甲醚 合成 

分 类 号：O636.1[理学—高分子化学]