圆柱状人工肝生物反应器中溶解氧浓度动态分布模型及其氧浓度变化速率  

Model of Dynamic Distribution of Dissolved Oxygen Concentration and Oxygen Concentration Changing Rate of Hepatocyte in a Cylindrical Reactor of Bioartificial Liver

作　　者：刘剑峰[1,2] 宋涛[1] 王喆[1,2] 姜薇[1] 

机构地区：[1]中国科学院电工研究所,北京100190 [2]中国科学院研究生院,北京100049

出　　处：《过程工程学报》2010年第1期10-16,共7页The Chinese Journal of Process Engineering

基　　金：国家高技术研究发展计划(863);重大基金资助项目(编号:2006AA02A140)

摘　　要：从人工肝治疗的需要出发,建立了圆柱状专用生物反应器中溶解氧浓度动态分布的数学机理模型,并分析了反应器内部实时氧浓度变化速率,设计出了溶氧变化的在线检测方法,结合模型推导出反应器内部总氧浓度变化量与实时氧浓度变化速率之间的关系.通过仿真数据与实测实验的对比验证了该模型的正确性,其平均误差在±5%以内,氧浓度变化速率误差在±1%以内,验证了总氧浓度变化量δDO与实时氧浓度变化速率R之间满足δDO=MNΔhR/V.A mathematic mechanism model of dynamic distribution of dissolved oxygen concentration in a cylindrical bio-reactor was built up based on the modeling method of artificial liver bioreactor. Oxygen concentration changing rate of hepatocyte was analyzed on the basis of the model, a real-time detection method advanced, and the relationship between the real-time oxygen concentration changing rate and the total oxygen concentration changing derived. Finally, the comparison between simulation data and measured data verified the correctness of model, and the average error was within 5%, and the error of oxygen concentration changing rate within 1%. In the meantime, the experimental results verified the relationship between the total oxygen concentration changing and real-time oxygen concentration changing rate, a correlation was obtained as δDO=MN△hR/V.

关 键 词：生物反应器 模型 溶解氧浓度 肝细胞培养 生物人工肝支持系统 氧浓度变化速率 总氧浓度变化量 

分 类 号：TP273[自动化与计算机技术—检测技术与自动化装置] R318[自动化与计算机技术—控制科学与工程]