复方地塞米松乳膏中盐酸赛庚啶的含量测定  

Determination of cyproheptadine hydrochloride of compound dexamethasone cream

作　　者：范博[1] 赵瑞玲[2] 丁红[1] 徐雅贞[1] 

机构地区：[1]山西医科大学药剂学教研室,太原030001 [2]山西省儿童医院药剂科

出　　处：《山西医科大学学报》2010年第2期140-141,共2页Journal of Shanxi Medical University

摘　　要：目的建立复方地塞米松乳膏中盐酸赛庚啶的含量测定方法。方法采用紫外分光光度法测定复方地塞米松乳膏中盐酸赛庚啶的含量,检测波长为284nm。结果盐酸赛庚啶在5.0-30.0μg/ml(r=0.9999)范围内,线性关系良好,平均回收率为100.0%,RSD为0.94%(n=9)。结论紫外可见分光光度法可用于本制剂的含量测定和质量控制,方法简便、灵敏,结果准确。Objective To establish a method for determining the content of cyproheptadine hydrochloride in compound dexamethasone cream. Methods A ultraviolet spectrophotometric method was used for the determination of cyproheptadine hydrochloride in compound dexamethasone cream. The detection wavelength was at 284 nm. Results The linear range for the cyproheptadine hydrochloride was 5.0 - 30.0 μg/ml （ r = 0.999 9）. The average recovery rate was 100.0% ,and RSD was 0.94% （ n = 9）. Conclusion The method is accurate,reliable, simple and feasible, and could be used for the quality control and the deteirmination of cyproheptadine hydrochloride in compound dexamethasone cream.

关 键 词：紫外分光光度法 复方地塞米松乳膏 盐酸赛庚啶 含量测定 

分 类 号：R927.2[医药卫生—药学]