康普瑞丁自乳化药物传递系统的筛选及质量评价  

Design and quality evaluation of self-emulsifying drug delivery systems for Combretastatin A4

作　　者：栾长涛[1] 孙逊[1] 袁志翔[1] 龚涛[1] 张志荣[1] 

机构地区：[1]四川大学华西药学院靶向药物与释药系统教育部重点实验室,四川成都610041

出　　处：《华西药学杂志》2010年第1期9-12,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的制备康普瑞丁(Combretastatin A4,CA4)自乳化药物传递系统(SEDDS),并评价其质量。方法利用假三相图法,根据乳化后的外观和粒径筛选最优处方,并对自乳化制剂中药物的溶解度、在不同溶出介质中的溶出特点等质量指标进行了考察。结果最优处方为CA4-Lauroglycol FCC-T20C-Transcutol P(3∶50∶35∶15),自乳化制剂的药物溶解度为66mg·mL-1,在3种溶出介质中药物溶出效果相近,10min基本释放完全。结论自乳化制剂能明显提高CA4的溶解度,溶出介质对CA4自乳化制剂的体外溶出基本无影响。OBJECTIVE To prepare serf-emulsifying drug delivery systems （SEDDS） of combretastatin A4 and evaluate its quality. METHODS The best formulation was optimized according to appearance and particle size of emulsions with ternary phase diagrams and the solubility and dissolution characteristics of SEDDS in three different medias were investigated. RESULTS The best formulation was CA4 - Lauroglycol FCC - T20C - Transcutol P with weight ratio of 3 ： 50 ： 35 ： 15. The solubility of CA4 SEDDS was 66 mg·mL^-1, and the drug totally released in 10 minutes in three media, suggesting that the effects of dissolution in three medias was close. CONCLUSION The self - emulsifying formulation can obviously improve the solubility of CA4 and the dissolution characteristics of CA4 SEDDS was not affected by different dissolution media.

关 键 词：康普瑞丁 自乳化 溶出 

分 类 号：R94[医药卫生—药剂学]