丹皮酚经皮给药系统的研究  

Study on transdermal drug delivery system of paeonol

作　　者：李志[1] 刘洋[1] 王盼[1] 

机构地区：[1]郑州大学药学院,河南郑州450001

出　　处：《华西药学杂志》2010年第1期12-14,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的以脂溶性药物丹皮酚为模型药物,制备载药传递体,评价其质量并进行小鼠经皮渗透体外研究。方法采用薄膜分散-超声法制备丹皮酚传递体;以改进的Franz扩散池进行体外小鼠经皮渗透实验,比较不同处方组成对丹皮酚经皮渗透的影响。结果丹皮酚传递体为乳白色、近透明的胶体溶液。脂质传递体、普通脂质体和丹皮酚水醇混悬液8h时的累积渗透率分别为81.22%、49.66%、42.22%。结论丹皮酚传递体制备工艺简单可行,所制传递体的粒径较小且均匀,并可促进丹皮酚的经皮转运。OBJECTIVE To prepare paeonol - loaded transfersomes and charecterize the transdermal effects in vitro. METHODS Paeonol transfersomes were prepared by thin - film ultrasonic method. The different dosage regimes on the trandermal resorption of paeonol were evaluated through excised mice skin in vitro using modified Franz - diffustion cells. RESULTS The average particle size of the paeonol transfersome optimized formula was evenly distributed. The cumulative penetration rate in 8 h of transfer＇some with cholesterol were 81.22%. Conventional liposome was 49.66%. Paeonol water - alcohol suspension was 42.22%. CONCLUSION The preparation method of paeonol transfersome was simple and suitable. The particle size are relatively small and homogeneous,and can improve significantly the transdermal delivery speed of paeonol.

关 键 词：丹皮酚 脂质传递体 透皮吸收 体外 

分 类 号：R94[医药卫生—药剂学]