趋化因子受体6在子宫内膜异位症在位内膜及异位灶中的表达  

The expression of CCR6 in eutopic and ectopic endometrium of endometriosis

作　　者：罗雪珍[1] 李大金[1] 史颖莉[1] 王凌[1] 

机构地区：[1]复旦大学上海医学院附属妇产科医院暨妇产科研究所,200011

出　　处：《中国妇产科临床杂志》2010年第1期34-36,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：国家重大科学研究计划项目(2006CB944007);上海市重点学科建设项目(B117)资助

摘　　要：目的分析趋化因子受体6(chemokine receptor,CCR6)在子宫内膜异位症(内异症)患者的在位内膜及异位内膜中的表达水平,以探讨其在发病中的作用。方法采用免疫组化技术检测内异症患者在位内膜及异位灶CCR6的表达。结果对照组子宫内膜中CCR6的表达分泌期明显强于增殖期(P<0.05);内异症患者在位子宫内膜间质和腺体CCR6的表达比较,差异无统计学意义(P>0.05),但其表达强度高于对照组(P<0.05),异位灶CCR6的表达明显高于对照组(P<0.05),略高于在位子宫内膜,但无统计学意义(P>0.05)。结论CCR6的表达具有周期特异性,可能受雌/孕激素调节,参与子宫内膜异位症的发生和进展。Objective To evaluate the expression levels of chemokine receptor 6 （CCR6） in the eutopic endometrium and ectopic endometrium of patients with endometriosis,and to study the pathogenesis of endometriosis. Methods Immunohistochemistry was used to detect the protein expression of CCR6 in the eutopic endometrium and ectopic foci of endometriosis,with the endometrium of fertile women who had no endometriosis as control. Results The expression of CCR6 in the secretory phase of control endometrium was significantly higher than that of the proliferative phase of control endometrium （P0.05）. There was no significant difference in the expression of CCR6 in the glands and the stroma of eutopic endometrium of endometriosis （P0.05）.But the expression of CCR6 was much higher in eutopic endometrium than that of control endometrium. （P0.05）. The expression of CCR6 in ectopic endometrium was significantly higher than that of control endometrium （P0.05）,also higher than eutopic endometrium,but had no significant differences. （P0.05）. Conclusion The results indicates that CCR6 may be involved in the pathogenesis and development of endometriosis.

关 键 词：子宫内膜异位症 趋化因子 受体 趋化因子受体6 

分 类 号：R711.71[医药卫生—妇产科学] R512.91[医药卫生—临床医学]