寻常性银屑病患者血清sCD40L水平及甲氨蝶呤的干预作用  

Affection of MTX on Serum Levels of sCD40L in the Patients with Psoriasis Vulgaris

作　　者：罗权[1,2] 林玲[2] 曾抗[1] 刘玉梅[2] 朱慧兰[2] 何玉清[2] 张锡宝[2] 

机构地区：[1]南方医科大学南方医院皮肤科,广东广州510515 [2]广州市皮肤病防治所,广东广州510095

出　　处：《中国皮肤性病学杂志》2010年第1期11-12,15,共3页The Chinese Journal of Dermatovenereology

基　　金：广东省自然科学基金(07001961);广州市医药卫生科研重点项目(2008-ZDi-05)

摘　　要：目的研究可溶性CD40配体(sCD40L)在寻常性银屑病发病中的作用及甲氨蝶呤(MTX)对其的调节作用,探讨MTX治疗银屑病的机制。方法应用双抗体夹心酶联免疫吸附法(ELISA)检测30例寻常性银屑病患者经MTX治疗前、后外周血清中sCD40L的水平变化。结果寻常性银屑病患者血清中sCD40L的水平显著高于经MTX治疗后及正常人对照组(P<0.05),其中进行期患者组显著高于静止期(P<0.05),且血清sCD40L浓度变化与寻常性银屑病严重程度指数PASI有相关性(r=0.435,P<0.05)。结论检测血清sCD40L水平有助于判断寻常性银屑病病情的严重程度,MTX可通过降低血清sCD40L水平而起到治疗作用。Objective To detect serum levels of sCD40L in the patients with psoriasis vulgaris and investigate the function of MTX. Methods Serum levels of sCIMOL in 30 patients （ before and alter treatment by MTX ） with psoriasis vulgaris and 20 healthy controls were measured by ELISA. Results Serum levels of sCD40L were significantly higher in the psoriasis vulgaris betore treatment than those after treatment and in normal controls （P 〈 0.05 ）. The serum levels were associated with psoriasis vulgaris stage and PASI （ r = 0. 435, P 〈 0.05）. Conclusions sCD40L levels in serum are associated with progressive stage and PASI of psoriasis vulgaris and they may serve as markers of psoriasis vulgaris. It is indicated that inhibiting the secretion of sCD40L may be involved in the treatment of psoriasis vulgaris with MTX.

关 键 词：银屑病 甲氨蝶呤 可溶性CD40配体 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]