应用TRUST和FTA-ABS-IgM试验判愈梅毒的探讨  

Approach to Determining Clinical Cure of Treated Syphilis Patients with TRUST and FTA-ABS-IgM

作　　者：杨琳[1] 刘文力[1] 

机构地区：[1]沈阳市第七人民医院皮肤科,辽宁沈阳110003

出　　处：《中国皮肤性病学杂志》2010年第1期55-56,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨梅毒螺旋荧光抗体IgM检测治疗后梅毒患者复查结果的临床意义。方法1503例梅毒患者经驱梅治疗后在不同时期复查,收集血清标本进行甲苯胺红血清不加热试验(TRUST)、IgG梅毒螺旋体明胶凝集试验(IgG-TPPA)及IgM荧光梅毒螺旋体抗体吸收试验(FTA-ABS-IgM)检测。结果各复查期限内FTA-ABS-IgM阳性率均高于TRUST阳性率,48例(48/1503,3.19%)TRUST持续阳性,经3次以上检测FTA-ABS-IgM均为阴性,判定为血清固定。结论TRUST可用于观察疗效,FTA-ABS-IgM可协助临床判定梅毒复发、再感染及临床治愈,对判定血清固定有重要意义。Objective To explore the clinical significance of detecting Treponema pallidum-IgM in the treated syphilis patients with FTA-ABS-IgM. Methods 1 503 serum specimen of the treated syphilis patients were examined by IgG-TPPA ,FTA-ABS-IgM and TRUST in different reexamination periods. Results The positive rate of FTA-ABS-IgM was higher than that of TRUST in different reexamination periods. 48 cases （48/1 503, 3.19% ）had continued positive TRUST and negative FTA-ABS-IgM for more than 3 reexaminations, judging them serum fixation. Conclusion TRUST may be used in observation of anti-syphilis treatment effect. FTA-ABS-IgM may provide clinic to judge whether recurrence, reinfection and cure of syphilis or not, and play an important role in serum fixation .

关 键 词：梅毒 甲苯胺红血清不加热试验 荧光梅毒螺旋体抗体吸收试验 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]