活动期系统性红斑狼疮患者脂代谢紊乱与重要脏器损害的关系探讨  

Dyslipidemia and important organ damages.in patients with active systemic lupus erythematosus

作　　者：郭惠芳[1] 彭晨星[1] 张明峰[1] 邵福灵[1] 高丽霞[1] 张清[1] 刘凤珍[1] 

机构地区：[1]河北医科大学第二医院免疫风湿科,石家庄050000

出　　处：《中华风湿病学杂志》2010年第1期33-36,共4页Chinese Journal of Rheumatology

基　　金：河北省卫生厅医学科学研究重点课题计划基金（2006010）

摘　　要：目的探讨活动期系统性红斑狼疮（SLE）患者血脂水平变化与脏器损害的关系。方法收集71例活动期SLE患者和30名健康对照者临床资料，分析血脂变化。结果活动期SLE患者平均血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、载脂蛋白B100（aPoB）水平均高于健康对照组，高密度脂蛋白胆固醇（HDL）、apoAl水平显著低于健康对照组（P〈0．05或P〈0．01）。有重要脏器损害患者的病程较长，血清TC、TG、LDL和apoB水平显著高于无脏器损害患者（P〈0．05或P〈0．01），尤其并发心血管病患者更明显（P〈0．01）。TC、TG、LDL,apoB水平与病程呈正相关（P〈0．05或P〈0．01），与C3水平呈负相关（P〈0．05或P〈0．01），TC和LDL与c4水平呈负相关（P〈0．05）。结论活动期SLE患者存在严重脂代谢紊乱，且脂代谢紊乱与病程、疾病活动性和重要脏器损害密切相关。Objective To investigate the correlation between dyslipidemia and important organ damage in patients with active systemic lupus erythematosus （SLE） without treatment. Methods Serum samples from 71 active SLE patients and 30 healthy controls were obtained to measure lipid profiles including total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL）, low-density lipoprotein cholesterol （LDL）, apolipoproteinA1 （apoA1）, apolipoproteinB100 （apoB） and lipoprotein a （LPa）. Clinical parameters were recorded. Results The levels of serum TC, TG, LDL, apoB in active SLE patients were higher than those in healthy controls, in contrast,the levels of HDL,apoA1 were much lower （P〈0.05 or P〈 0.01 ）. Patients with important organ damages had longer disease course and elevated levels of serum TC, TG, LDL and apoB concentrations than those without organ damage （P〈0.05 or P〈0.01 ）, especially in patients with cadiovascular diseases （CVD） （P〈0.01）. Moreover, these changes in lipid metabolism were positively correlated with disease course and negatively with C3 level （P〈0.05 or P〈0.01 ）. The elevated serum TC and LDL concentrations were negatively correlated with C4 level （P〈0.05）. Conclusion Severe dyslipidemia is present in active SLE patients.It is correlated with disease course and disease activity. Increased serum TC, TG, LDL and apoB concentrations play key roles in patients with important organ damages.

关 键 词：红斑狼疮 系统性 高脂血症 器官损害 

分 类 号：R593.241[医药卫生—内科学]