苍白球功能变化与帕金森症  

Functional change of globus pallidus and Parkinson's disease

作　　者：王广鹤[1] 许海燕[1] 陈瑞瑞[1] 何德富[1] 

机构地区：[1]华东师范大学环境科学系生理学实验室,上海200062

出　　处：《中国病理生理杂志》2010年第2期396-400,共5页Chinese Journal of Pathophysiology

摘　　要：As an important nucleus of basal ganglia,globus pallidus was concerned to involve in the neural mechanism of Parkins’s disease (PD). Previous studies of PD patients and animal model indicate that neurotransmitters and receptors are changed in globus pallidus neurons,the balance between inhibition and excitation is broken in the output nuclei of basal ganglia,and globus pallidus neurons display bursting and oscillatory discharge,the synchronous tendency of neighboring neurons enhances. These neurophysiological changes are associated with PD symptoms,such as bradykinesia,rigidity and tremor,which reflects that globus pallidus plays an important role in the process of PD. In the present paper,the recent advances in pathophysiology in globus pallidus,its clinical application in treatment of Parkinson’s disease,and the study direction in the future are reviewed.As an important nucleus of basal ganglia, globus pallidus was concerned to involve in the neural mechanism of Parkins＇s disease （PD）. Previous studies of PD patients and animal model indicate that neurotransmitters and receptors are changed in globus pallidus neurons, the balance between inhibition and excitation is broken in the output nuelei of basal ganglia, and globus pallidus neurons display bursting and oscillatory, discharge, the synchronous tendency of neighboring neurons enhances. These neurophysiological changes are associated with PD symptoms, such as bradykinesia, rigidity and tremor, which reflects that globus pallidus plays an important role in the process of PD. In the present paper, the recent advances in pathophysiology in globus pallidus, its clinical application in treatment of Parkinson＇s disease, and the study direction in the future are reviewed.

关 键 词：帕金森病 苍白球 多巴胺 谷氨酸 

分 类 号：Q426[生物学—神经生物学]