把人体皮肤成纤维细胞重编程为干细胞  

Reprogramming the human skin fibroblast cell into stem cell

作　　者：钟秉政[1] 黄巧冰[2] 

机构地区：[1]南方医科大学第一临床医学院,广东广州510515 [2]南方医科大学基础医学院,广东广州510515

出　　处：《基础医学与临床》2010年第2期209-211,共3页Basic and Clinical Medicine

摘　　要：近年来,关于人体干细胞的研究,特别是将已分化细胞(如人皮肤的成纤维细胞)转化成人体胚胎干细胞的研究取得了突破性进展。在反转录因子OCT3/4、SOX2、C-MYC和KLF4的作用下,人皮肤的成纤维细胞可以转变为多能干细胞,具备了多种干细胞的能力,有望在多种疾病的机制研究和治疗中发挥重要的作用。本文将对这项最新的研究成果进行介绍。In recent years, researchers have made some breakthroughs on human embryonic stem cells, in particular, on reprogramming differentiated cell （such as human skin fibroblast） into human embryonic stem cell. Induced pluripotent stem cells could be generated from human skin fibroblasts by inducting into four transcription factors known as OCT3/4, SOX2, C-MYC and KLF4. This approach enables better understanding the pathogenesis of diseases from the perspective of genetic component and promising in the treatment of related diseases. This article introduces the latest advancement of those researches.

关 键 词：人体成纤维细胞 干细胞 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]