小檗碱和利多卡因抗实验性心律失常作用  

Anti-arrhythmic Effects of Berberine and Comparison with Lidocaine

作　　者：杨静[1] 王巧云[1] 

机构地区：[1]滨州医学院烟台校区机能学实验室,264003

出　　处：《中国现代药物应用》2010年第3期14-15,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探索小檗碱的抗心律失常作用并与利多卡因相比较。方法注射肾上腺素诱导家兔实验性心律失常模型,经静脉注射小檗碱、钠通道阻滞剂利多卡因,分别观察其对肾上腺素致家兔心律失常的影响。结果利多卡因、小檗碱均使心律失常持续时间缩短。随着小檗碱浓度的增加,心律失常持续时间缩短(P<0.01)。结论小檗碱具有抗实验性室性心律失常作用。Objective To study the anti-arrhythmic effects of Berberine and comparison with lidocaine. Methods Induced ventricular arrhythmia by injected the anaesthetic rabbits with adrenaline, observe the effection of lidocaine and Berberine injected on the arrhythmic rabbits. Results Berberine and lidoeaine can shorten the arrhythmia time. The arrhythmic time was shortened the high Berberine concentration （P 〈 0. 01 ）. Conclusion The anti-arrhythmic action of Berberine was confirmed in the experimental models.

关 键 词：小檗碱 利多卡因 肾上腺素 心律失常 

分 类 号：R96[医药卫生—药理学]