盐酸普萘洛尔在碳纳米管修饰玻碳电极上的电化学行为及其应用  

Electrochemical behavior of propranolol hydrochloride at carbon nanotubes modified glassy carbon electrodes and its application

作　　者：李晓霞[1,2] 李延清[1] 王静[2] 王姝[2] 

机构地区：[1]延安大学,延安716000 [2]陕西师范大学化学与材料科学学院,西安710062

出　　处：《药物分析杂志》2010年第2期320-324,共5页Chinese Journal of Pharmaceutical Analysis

基　　金：陕西省教育厅科技项目(08JK488);延安市科学技术研究发展计划项目;延安大学科研项目的大力资助

摘　　要：目的:建立在碳纳米管修饰玻碳电极上测定盐酸普萘洛尔的新的电化学分析方法。方法:采用循环伏安法(CV)和微分脉冲伏安法(DPV)。结果:该法测定盐酸普萘洛尔的线性范围为0.20～17.7mg.L-1,检出限为0.09mg.L-1。对10.4mg.L-1盐酸普萘洛尔进行11次平行测定,相对标准偏差为2.1%。结论:碳纳米管修饰玻碳电极与裸玻碳电极相比,显著提高了盐酸普萘洛尔的氧化峰电流,降低了氧化峰电位,提高了测定的灵敏度。所建立的方法可用于盐酸普萘洛尔片剂中盐酸普萘洛尔含量的测定。Objective：A novel electrochemical method for the determination of propranolol hydrochloride was developed at multi-wall carbon nanotubes （MWNT） modified glassy carbon electrode （GCE）.Methods：The determination method was cyclic voltammetry（CV） and differential pulse voltammetry（DPV）.Results：There was a good linear relationship between anodic peak current and propranolol concentration in the range from 0.20 to 17.7 mg/L-1 and a detection limit of 0.09 mg/L-1 （S/N=3） was achieved.The relative standard derivation was 2.1% for 10.4 mg/L-1 propranolol hydrochloride in 11 repeated determinations.Conclusion：An irreversible oxidation peak was observed at the MWNT modified GCE at 0.961 V （vs.SCE） and the electrochemical response of propranolol was greatly enhanced compared with that of at bare GCE.The methods can be used for the determination of the drug in tablets with good results.

关 键 词：电化学 化学修饰电极 多壁碳纳米管 盐酸普萘洛尔 

分 类 号：R917[医药卫生—药物分析学]