阿片成瘾机制研究进展及治疗展望  

Mechanisms Underlying Opioid Addiction: New Progress

作　　者：王玢[1] 罗非[1] 韩济生[1] 

机构地区：[1]北京医科大学神经科学研究中心

出　　处：《生理科学进展》1998年第4期295-300,共6页Progress in Physiological Sciences

摘　　要：关于阿片类药物成瘾机制的研究是药物成瘾研究中的一个热点，本文从参与阿片成瘾的神经递质系统及其相互作用、不同阿片受体在成瘾过程中的作用、学习记忆与阿片成瘾的关系、成瘾性药物的细胞内信号转导机制等几个方面介绍了近年来的研究进展。The mechanisms of opioid addiction has attracted much attention of researchers around the world. In the present review, we have discussed the recent progress in the following topics. (1) Neurotransmitters participating the mechanism of opioid addiction; (2) Roles of different opioid receptors in opioid addiction; (3) Possible involvement of learning and memory in opioid addiction; (4) The intracellular signal transductive pathways after the activation of opioid receptors. Possible method of prevention and treatment of opioid addiction are also discussed.

关 键 词：阿片 成瘾 奖赏系统 成瘾机制 治疗 

分 类 号：R971[医药卫生—药品]