食物对口服雷贝拉唑肠溶胶囊吸收的影响研究  

The absorption of rabeprazole enteric-coated capsules was influenced by food taken at difference time in healthy volunteers

作　　者：欧宁[1] 张宏文[1] 王永庆[1] 陈安九[1] 袁红宇[1] 李子艳[1] 吴玲[1] 刘云[1] 

机构地区：[1]南京医科大学第一附属医院临床药理研究室,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2010年第1期17-19,68,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:研究饮食对健康志愿者口服雷贝拉唑肠溶胶囊在体内吸收的影响。方法:2名健康志愿者通过自身对照,先后口服雷贝拉唑肠溶胶囊各20mg,并分别于给药后2h及4h后进食标准餐。采用反相HPLC-UV法测定血中药物浓度。结果:健康志愿者口服雷贝拉唑肠溶胶囊后,2h和4h进食标准餐后的Cmax分别为(263.0±32.8)ng/ml和(360.6±105.0)ng/ml;Tmax分别为(6.5±0.7)h和(3.8±0.4)h;AUC0-10分别为(1203.1±228.0)μg·h/L和(1108.7±267.4)μg·h/L;T1/2分别为(3.2±0.21)h和(1.60±0.05)h。结论:食物可以影响雷贝拉唑肠溶胶囊的人体吸收,药物达峰时间明显延长。Objective：To evaluate the influence of food taken at different time in absorption of rabeprazole enteric-coated capsules in healthy volunteers.Methods：Two volunteers were enrolled in the study,and they were given rabeprazole enteric-coated capsules（20mg） at two different time points successively by own control,and took standard breakfast 2 or 4 hours after administration.Results：The pharmacokinetic parameters were as follows：Cmax：（263.0±32.8）ng/ml and（360.6±105.0）ng/ml;Tmax：（6.5±0.7）h and（3.8±0.4）h;t1/2：（3.2±0.21）h and（1.60±0.05）h;AUC0-10：（1203.1 ±228.0）μg·h/ L and（1108.7 ±267.4）μg·h/ L.Conclusion：The absorption of rabeprazole enteric-coated capsule was influenced by food,and Cmax was increased apparently.

关 键 词：雷贝拉唑 吸收 生物利用度 高效液相色谱法 

分 类 号：R969.1[医药卫生—药理学]