氟伐他汀对颈动脉斑块及hs-CRP和ET-1的影响  

Effect of Fluvastatin on the Carotid Artery Plaque and the Levels of hs-CRP and ET-1

作　　者：虞华鹏[1] 杨红英[1] 赵成军[1] 王涛[1] 贾如意[1] 

机构地区：[1]济南市第四人民医院济南市心血管病治疗中心,济南250031

出　　处：《中国医药导刊》2010年第1期48-49,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨氟伐他汀对颈动脉粥样斑块的消退作用及在斑块稳定性和炎症反应中的作用。方法:应用彩色多普勒超声检测出颈动脉粥样斑块形成者86例,随机分为观察组46例和对照组40例,观察组予以氟伐他汀40 mg/天,对照组予以饮食控制,均治疗一年,检测治疗前、后颈动脉粥样斑块的等级积分和Crouse积分,斑块数目,性质变化及血脂,血清高敏C-反应蛋白(hs-CRP)、内皮素-1(ET-1)水平。结果:观察组颈动脉粥样斑块的等级积分和Crouse积分,斑块数目,血脂,hs-CRP、ET-1水平均低于对照组,差异有统计学意义。结论:氟伐他汀可抑制炎症反应,改善内皮功能,稳定粥样斑块,并可有效消退颈动脉粥样斑块。Objective： To explore the effects of fluvastatin on the stability of carotid artery plaque and inflammatory reaction.Methods： 86 patients with arteriosclerosis plaque of carotid artery detected by uhrasound examination were randomly divided into observation group with 46 cases and control group with 40 cases. The patients of observation group were received fluvastatin 40 mg every day while control group were only given diet control. ALL patients were treated for one years. The levels of high-sensitivity C-reactive protein （hs-CRP）, endotbelin -1 （ET-I） and blood lipids, the changes of plaques number and carotid atherosclerosis grade points, Crouse points were detected before and after treatment.Results： All indicators including the levels of hs-CRP. ET-I and blood lipids, the plaques number and carotid atheroselerosis grade points, Crouse points in observation group were lower than those in control group.Conclusion： Fluvastatin can inhibit the inflammatory response and improve endothelial function. It also can improve the plaque stability and the regression of carotid artery plaque.

关 键 词：颈动脉粥样硬化 彩色多普勒超声 血清超敏C反应蛋白 肉皮素-1 

分 类 号：R543[医药卫生—心血管疾病]