抗环瓜氨酸肽(CCP)抗体与类风湿关节炎病情活动度及关节损害的关系探讨  

Relation of CCP antibody to mobility and damage of joints in patients with rheumatoid arthritis

作　　者：徐巍[1] 沈波[1] 陈世勇[1] 李俊[1] 袁兆林[1] 张晓雪[1] 

机构地区：[1]浙江省台州医院,浙江台州317000

出　　处：《中国卫生检验杂志》2010年第1期144-146,共3页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医药卫生科技计划资助项目(2007B225)

摘　　要：目的:分析抗环瓜氨酸肽(CCP)抗体对类风湿关节炎(RA)的诊断和评估意义,探讨抗CCP抗体与RA的病情活动度、关节侵蚀的关系。方法:用ELISA检测32例RA患者血清和关节液中的抗CCP抗体,并测定类湿因子(RF),记录RA患者的一些临床参数。对检测结果及临床参数进行统计分析。结果:抗CCP抗体阳性组与阴性组相比,年龄、关节肿胀个数、关节疼痛个数、DAS28、血沉及CRP等没有显著性差异(P>0.05);类风湿因子的阳性率在两组间的差异有统计学意义(P<0.05)。抗CCP抗体与年龄、关节肿胀个数、关节疼痛个数、DAS28、ESR和CRP等相关无显著性差异;抗CCP抗体与RF因子呈明显相关(r=0.639,P=0.001)。DAS28评分与关节肿胀个数、关节疼痛个数、DAS28、ESR和CRP显著相关,与年龄因素呈正相关,与类风湿因子的相关无统计学意义。结论:抗CCP抗体对RA的预后有一定的评估作用。Objective：To determine the value of determination of CCP antibody for diagnosis and evaluation of rheumatoid arthritis（RA）.Methods：ELLISA was used to determine CCP antibody in 32 patients with RA.Meanwhile,RF was determined and relevant clinical parameters recorded.Then statistical analysis of the data was performed.Results：There was no significant difference in age,joint damage number,joint pain,DAS28 and other indexes between the RA patients and controls（P〉0.05）.There was marked difference in RF positive rate between the 2 groups（P〈0.05）.The CCP antibody was not significantly correlated to joint damage number,joint pain,age,DAS28,ESR and CRP etc.However,it was remarkably correlated with RF（r=0.639,P=0.001）.DAS28 was correlated to joint damage number,joint pain,ESR,CRP and age but not to RF.Conclusion：CCP antibody can be used for predicting prognosis of RA.

关 键 词：抗环瓜氨酸肽抗体 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]