ICP-MS测定血中镁、铜、铅浓度时的基体效应单一内标校正方法研究  

Simultaneous Correction for Blood Matrix Effect on Determination of Magnesium,Copper and Lead Concentration in Blood Samples by ICP-MS Using CAIS

作　　者：杨乐[1] 曾静[1,2] 王小燕[1,2] 吴赞[3] 池海涛[3] 欧阳荔[1,2] 张经华[3] 王京宇[1,2] 

机构地区：[1]北京大学公共卫生学院,北京100191 [2]北京大学医药卫生分析中心生命元素组学实验室,北京100191 [3]北京市理化分析测试中心,北京100089

出　　处：《光谱学与光谱分析》2010年第2期518-522,共5页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(30770654);北京市自然科学基金项目(7062040)资助

摘　　要：ICP-MS测定模拟全血基体中不同质量段的Mg,Cu,Pb元素,考察基体效应对测定值的影响,分别采用传统内标法和单一内标CAIS方法(common analyte internal standardization)对其进行校正和比较。结果表明CAIS方法适用于不同浓度血液基体中多种元素的同时校正,且效果良好,其相对平均误差仅为3.05%,明显低于传统内标法的12.39%和校正前的23.91%;CAIS方法不受内标元素和被测元素质量数差异、测定强度差异以及电极电位差异的限制;使用全血和血清标准物质对CAIS方法可靠性进行验证,测定值全部落在标准值范围内。The influence of matrix effect on the determination of magnesium, copper and lead in human blood matrix stimulant and its correction was studied by using both conventional internal reference method ＆ common analyte internal standardization （CAIS）. The obtained results indicate that CAIS method is applicable for simultaneous correction of multi-elements in blood ma- trix- The relative errors between the determined and the true values are 3.05% （by CAIS method）, 12.39% （by conventional internal reference correction） and 23.91% （without correction）, respectively. Otherwise, the influences of the mass discrepancy and that of the determination intensities between elements are not obvious for the correction of blood matrix. The reliability of CAIS was validated by the determination of both bovine blood and bovine serum standard materials.

关 键 词：CAIS 基体效应 镁 铜 铅 

分 类 号：O657.3[理学—分析化学]