利多卡因丝素蛋白双层膜制备及其生物相容性研究  

Preparation of lidocaine silk double-deck membrane and its biocompatibility

作　　者：吴莉[1] 周欣颖[1] 张学农[1] 

机构地区：[1]苏州大学药学院,苏州215123

出　　处：《中国新药杂志》2010年第2期161-167,共7页Chinese Journal of New Drugs

基　　金：国家科技支撑计划课题(2006BAI09B00);国家科技部科技型中小企业技术创新基金(07C26223201333)

摘　　要：目的:制备盐酸利多卡因丝素蛋白双层膜,并研究其体外释放、透皮吸收特性和生物相容性。方法:以甘油为增塑剂,制备丝素蛋白甘油双层膜;以渗透促进速率为指标,均匀设计优化双层膜中处方工艺;与单层膜比较,考察了丝素蛋白双层膜的释放性能;考察利多卡因丝素蛋白双层膜的生物相容性。结果:丝素蛋白双层膜的体外释药和透皮吸收均符合Higuchi方程,丙二醇为2.0%,氮酮为1.6%的复合透皮促进剂可明显促进药物的透皮吸收;双层丝素膜的释放性能优于单层膜;其生物相容性良好。结论:丝素蛋白双层膜可作为经皮吸收药物的理想载体,具有良好的应用前景。Objective：To prepare a silk compound membrane of lidocaine hydrochloride and study its in vitro release characteristics and biocompatibility. Methods：The silk compound membrane was prepared with glycerine as elastieizer. The prescriptions of formulation and preparation process were screened by the uniform design for permeation rate. The release characteristics of silk compound membrane was studied and compared with the monolayer one. The biocompatibility of silk compound membrane of lidocaine was investigated. Results： The release mechanism of silk compound membrane of lidocaine in vitro was coincided with Higuchi Equation,and the release characteristics of compound membrane was better than the monolayer one. The transdermal absorption reached peak when the ratio of azone to propylene glycol was 1.6%：2.0%. The biocompatibility is good. Conclusion：Silk compound membrane is effective as vehicle for transdermal therapeutic drugs,also has a satisfactory prospect.

关 键 词：丝素双层膜 均匀设计 体外释放 透皮吸收 生物相容性 

分 类 号：R943.43[医药卫生—药剂学] R971.2[医药卫生—药学]