^(18)F-FDG PET/CT显像对胃肠道恶性肿瘤分期、术后再分期诊断的临床价值  

Value of ^(18)F-FDG PET/CT Imaging on Diagnosis, Staging, Restaging for Gastrointestinal Tumor

作　　者：朱峰[1] 王跃涛[1] 钱作宾[1] 鹿峰[1] 刘德峰[1] 

机构地区：[1]东南大学医学院附属徐州医院PET-CT中心,江苏徐州221009

出　　处：《中国医疗设备》2010年第1期127-130,共4页China Medical Devices

摘　　要：目的评价18F-FDG PET/CT显像对胃肠道恶性肿瘤分期、术后再分期诊断的临床价值。方法回顾性分析25例原发及52例胃肠道肿瘤术后患者全身PET/CT显像结果。原发灶皆经组织病理学检查确诊(手术或内窥镜活检术取得病理组织),确诊肿瘤复发、转移的依据为再次手术后病理、胃镜、结直肠镜、多种影像学检查及临床随访,本组随访6~32个月,平均17个月。结果25例原发胃肠道肿瘤患者,PET/CT对肿瘤原发病灶诊断准确率96%(24/25)。PET/CT分期诊断的灵敏度83.3%(10/12),特异度92.3%(12/13),阳性预测值90.9%(10/11),阴性预测值85.7%(12/14),准确度88%(22/25)。PET/CT再分期诊断的灵敏度97.1%(34/35),特异度82.4%(14/17),阳性预测值91.9%(34/37),阴性预测值93.3%(14/15),准确度92.3%(48/52)。治疗方案改变28.6%(22/77)。结论PET/CT能准确、灵敏地检测胃肠道肿瘤原发病灶、转移以及复发病灶,对临床治疗决策有重要影响。18F-FDGPET/CT显像对胃肠道恶性肿瘤的分期、术后再分期诊断有较高的临床价值。Objective To investigate the clinical value of fluorine-18-labeled fluorodeoxyglucose（^18F-FDG） positron emission tomograpy/computed tomograpy（PET/CT） imaging on diagnosis, staging, restaging for gastrointestinal tumor. Methods The results of PET/CT over 75 patients with gastrointestinal tumors were retrospectively reviewed. The primary lesions were all proved by pathology. The diagnosis of recurrence tumor and/or metastasis was based on pathologic examination, colonoscopy, multi-modality imaging and clinical follow-up. The average follow-up time was 17 months. Results The primary tomour was visualized in 96%（24/25） with PET/CT. The sensitivity,specificity, positive predictive value（PPV）,negative predictive value（NPV） and accuracy of PET/CT in staging were 83.3%（10/12）,92.3%（12/13）, 90.9%（10/11）,85.7%（12/14）and 88%（22/25）respectively. The sensitivity,specificity,PPV,NPV and accuracy of PET/CT in restaging were 97.1%（34/35）,82.4% （14/17）,91.9%（34/3 7）,93.3%（14/15）and 92.3%（48/52）respectively. The clinical therapeutic strategies were changed in 22 cases due to the results of PET/CT,and the influence rate of PET/ CT was 28.6 %（22/77）.Conclusion PET/CT can detect the primary lesions, recurrence and metastasis of gastrointestinal tumor with high sensitivity and accuracy. F-FDG PET/CT imaging 18 has increased accuracy of the diagnosis, staging, restaging for gastrointestinal tumor.

关 键 词：胃肠道肿瘤 诊断 分期 再分期 PET/CT 

分 类 号：R817.4[医药卫生—影像医学与核医学]