阻断肾素-血管紧张素-醛固酮系统不同环节对Goldblatt鼠左心室重构和收缩功能影响  

Effect of blocking the different links of RAAS on Left ventricular function in Goldblatt rat

作　　者：刘宇飞[1] 曲鹏[1] 龙晓凤[1] 王圣[1] 王丽萍[1] 

机构地区：[1]大连医科大学附属第二医院急诊科,116023

出　　处：《心肺血管病杂志》2010年第1期49-52,共4页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:观察缬沙坦及螺内酯对Goldblatt鼠左心室重构和收缩功能的影响。方法:SD大鼠随机分为高血压组(N)、缬沙坦组(V)、螺内酯组(S)、缬沙坦及螺内酯组(S+V组)和假手术组(C组)。术后第10周,用放免法测定心肌组织中的血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)。结果:术后10周N组大鼠血压、收缩期经线室壁应力(MESS)、舒张末期左心室后壁厚度(LVPWD)及舒张末期室间隔厚度(IVSD)较C组明显升高(P<0.01)。与N组相比V组和S+V组血压、MESS、LVPWd及IVSd均明显低于N组(P<0.05);S组则无明显改善(P>0.05);N组AngⅡ和ALD浓度显著高于C组(P<0.01),S组ALD含量显著高于C组(P<0.05),V组及S+V组ALD低于N组(P<0.05)。S组、V组及S+V组AngⅡ含量显著低于N组(P<0.05)。结论:在Goldblatt鼠模型中,压力负荷及RAAS系统对左心室肥厚的形成起重要的作用。缬沙坦可以降低血压,改善心功能。螺内酯可以部分地降低血压、逆转左心室肥厚。Objective：To discuss whether spironolactone and valsartan interfere with the left ventricular（LV） function in Goldblatt rats.Methods：Two-kidney,one-clip（2K1C） renovascular hypertension was induced in forty-six male Sprague-Dawley rats.The rats were randomized to untreated hypertension group （group N）,spironolactone treatment group（group S）.Valsartan treatment group（group V）,spironolactone and valsartan treatment group（group S＋V）.Ten Sham-operated rats served as the control group（group C）.After 8 weeks of treatment,Left ventricle concentration of AngⅡ and aldosterone were assessed by radioimmunoassay.Results： The blood pressure is higher in N group and S group than V、S＋V and C groups（P0.05）.LVH can be observed in N group and S group,but not in the V、S＋V and C groups.The levels of AngⅡ in LV of N group were much higher than the other four groups（P0.05）.The levels of ALD in LV of C group were much lower than the other four groups（P0.05）,and that of S group was higher than C group.Conclusion： The overload plays the important roles to the development of LVH.Treating with spironolactone can decrease partly.Valsartan can inhibit the development of LVH and contribute to systolic dysfunction of Goldblatt Rat.

关 键 词：左心室肥厚 血管紧张素Ⅱ 醛固酮 

分 类 号：R54[医药卫生—心血管疾病]